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Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork

PURPOSE: Abnormal accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) is associated with decreased aqueous humor outflow facility and IOP elevation in POAG. Previously, we have developed a transgenic mouse model of POAG (Tg-MYOC(Y437H)) by expressing human mutant myocilin (MYO...

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Detalles Bibliográficos
Autores principales:	Kasetti, Ramesh B., Phan, Tien N., Millar, J. Cameron, Zode, Gulab S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2016
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102566/ https://www.ncbi.nlm.nih.gov/pubmed/27820874 http://dx.doi.org/10.1167/iovs.16-19610

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