Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin

This article reports the clinical investigation of a probe drug cocktail containing substrates of key drug transporters. Single oral doses of 0.25 mg digoxin (P‐gp), 5 mg furosemide (OAT1 and OAT3), 500 mg metformin (OCT2, MATE1, and MATE2‐K), and 10 mg rosuvastatin (OATP1B1, OATP1B3, and BCRP) were...

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Detalles Bibliográficos
Autores principales: Stopfer, P, Giessmann, T, Hohl, K, Sharma, A, Ishiguro, N, Taub, ME, Zimdahl‐Gelling, H, Gansser, D, Wein, M, Ebner, T, Müller, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102573/
https://www.ncbi.nlm.nih.gov/pubmed/27256812
http://dx.doi.org/10.1002/cpt.406

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