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Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology

AIMS: Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for some of the cognitive impairment not fully explained by Alzheimer‐t...

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Detalles Bibliográficos
Autores principales:	Simpson, Julie E., Ince, Paul G., Minett, Thais, Matthews, Fiona E., Heath, Paul R., Shaw, Pamela J., Goodall, Emily, Garwood, Claire J., Ratcliffe, Laura E., Brayne, Carol, Rattray, Magnus, Wharton, Stephen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102584/ https://www.ncbi.nlm.nih.gov/pubmed/26095650 http://dx.doi.org/10.1111/nan.12252

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