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Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India

In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits e...

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Autores principales: John, Mathew, Koledova, Ekaterina, Kumar, Kanakatte Mylariah Prasanna, Chaudhari, Harshal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102730/
https://www.ncbi.nlm.nih.gov/pubmed/27867396
http://dx.doi.org/10.1155/2016/2967578
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author John, Mathew
Koledova, Ekaterina
Kumar, Kanakatte Mylariah Prasanna
Chaudhari, Harshal
author_facet John, Mathew
Koledova, Ekaterina
Kumar, Kanakatte Mylariah Prasanna
Chaudhari, Harshal
author_sort John, Mathew
collection PubMed
description In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits estimation of the magnitude of this problem. The diagnosis and treatment of GHD are hurdled with various challenges, restricting the availability of growth hormone (GH) therapy to only a very limited segment of the children in India. This review will firstly summarize the gaps and challenges in diagnosis and treatment of GHD based on literature analysis. Subsequently, it presents suggestions from the members at advisory board meetings to overcome these challenges. The advisory board suggested that early initiation of the therapy could better the chances of achieving final adult height within the normal range for the population. Education and awareness about growth disorders among parents, regular training for physicians, and more emphasis on using the Indian growth charts for growth monitoring would help improve the diagnosis and treatment of children with GHD. Availability of an easy-to-use therapy delivery system could also be beneficial in improving adherence and achieving satisfactory outcomes.
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spelling pubmed-51027302016-11-20 Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India John, Mathew Koledova, Ekaterina Kumar, Kanakatte Mylariah Prasanna Chaudhari, Harshal Int J Endocrinol Review Article In clinical practice, every year approximately 150,000 children are referred with short stature (SS) based on a cut-off of fifth percentile. The most important endocrine and treatable cause of SS is growth hormone deficiency (GHD). The lack of reliable data on the prevalence of GHD in India limits estimation of the magnitude of this problem. The diagnosis and treatment of GHD are hurdled with various challenges, restricting the availability of growth hormone (GH) therapy to only a very limited segment of the children in India. This review will firstly summarize the gaps and challenges in diagnosis and treatment of GHD based on literature analysis. Subsequently, it presents suggestions from the members at advisory board meetings to overcome these challenges. The advisory board suggested that early initiation of the therapy could better the chances of achieving final adult height within the normal range for the population. Education and awareness about growth disorders among parents, regular training for physicians, and more emphasis on using the Indian growth charts for growth monitoring would help improve the diagnosis and treatment of children with GHD. Availability of an easy-to-use therapy delivery system could also be beneficial in improving adherence and achieving satisfactory outcomes. Hindawi Publishing Corporation 2016 2016-10-27 /pmc/articles/PMC5102730/ /pubmed/27867396 http://dx.doi.org/10.1155/2016/2967578 Text en Copyright © 2016 Mathew John et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
John, Mathew
Koledova, Ekaterina
Kumar, Kanakatte Mylariah Prasanna
Chaudhari, Harshal
Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
title Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
title_full Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
title_fullStr Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
title_full_unstemmed Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
title_short Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India
title_sort challenges in the diagnosis and management of growth hormone deficiency in india
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102730/
https://www.ncbi.nlm.nih.gov/pubmed/27867396
http://dx.doi.org/10.1155/2016/2967578
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