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The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation

Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Wang, Shuo, Yang, Cheng, Rong, Ruiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102737/
https://www.ncbi.nlm.nih.gov/pubmed/27868073
http://dx.doi.org/10.1155/2016/4986797
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author Zhang, Chao
Wang, Shuo
Yang, Cheng
Rong, Ruiming
author_facet Zhang, Chao
Wang, Shuo
Yang, Cheng
Rong, Ruiming
author_sort Zhang, Chao
collection PubMed
description Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural killer cells, dendritic cells, macrophages, natural killer T cells, and regulatory T cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. Considering their strong immunosuppressive capability, MDSCs could become a prospective clinical regimen during transplantation tolerance induction, resulting in long-term graft survival with decreased or without immunosuppressive drugs. The review summarized recent research advances in this field and looked ahead at the research directions in the future.
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spelling pubmed-51027372016-11-20 The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation Zhang, Chao Wang, Shuo Yang, Cheng Rong, Ruiming J Immunol Res Review Article Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural killer cells, dendritic cells, macrophages, natural killer T cells, and regulatory T cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. Considering their strong immunosuppressive capability, MDSCs could become a prospective clinical regimen during transplantation tolerance induction, resulting in long-term graft survival with decreased or without immunosuppressive drugs. The review summarized recent research advances in this field and looked ahead at the research directions in the future. Hindawi Publishing Corporation 2016 2016-10-27 /pmc/articles/PMC5102737/ /pubmed/27868073 http://dx.doi.org/10.1155/2016/4986797 Text en Copyright © 2016 Chao Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Chao
Wang, Shuo
Yang, Cheng
Rong, Ruiming
The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
title The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
title_full The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
title_fullStr The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
title_full_unstemmed The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
title_short The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation
title_sort crosstalk between myeloid derived suppressor cells and immune cells: to establish immune tolerance in transplantation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102737/
https://www.ncbi.nlm.nih.gov/pubmed/27868073
http://dx.doi.org/10.1155/2016/4986797
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