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Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report
Palonosetron is a 5-hydroxytryptamine-3 (5-HT-3) receptor antagonist used for preventing postoperative nausea and vomiting. Compared with ondansetron and granisetron, it is a better drug because of prolonged action and minimal side effects. Some adverse effects of palonosetron have been reported. In...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102841/ https://www.ncbi.nlm.nih.gov/pubmed/27826967 http://dx.doi.org/10.4168/aair.2017.9.1.92 |
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author | Park, Hyungjun Oh, Kyunghwan Lee, Hoonhee Lee, Ji-Hyang Kang, Sun-myoung Park, So-Young Kwon, Hyouk-Soo Cho, You Sook Moon, Hee-Bom Kim, Tae-Bum |
author_facet | Park, Hyungjun Oh, Kyunghwan Lee, Hoonhee Lee, Ji-Hyang Kang, Sun-myoung Park, So-Young Kwon, Hyouk-Soo Cho, You Sook Moon, Hee-Bom Kim, Tae-Bum |
author_sort | Park, Hyungjun |
collection | PubMed |
description | Palonosetron is a 5-hydroxytryptamine-3 (5-HT-3) receptor antagonist used for preventing postoperative nausea and vomiting. Compared with ondansetron and granisetron, it is a better drug because of prolonged action and minimal side effects. Some adverse effects of palonosetron have been reported. In this report, we describe a 37-year-old male who developed severe hypersensitivity reactions to palonosetron during surgery for kidney donation. His medical history was unremarkable, except for inguinal hernia with herniorrhaphy 8 years ago. The surgery was uneventful until 2 hours 20 minutes. After palonosetron injection, his blood pressure dropped to 80/50 mm Hg, and facial edema, rash, conjunctival swelling, and wheezing developed. The patient was resuscitated by administration of ephedrine, hydrocortisone, and peniramine. Following the surgery, the patient was monitored for 3 days, and there were no subsequent anaphylactic reactions or other complications. The skin test on postoperative day 54 was positive for hypersensitivity to palonosetron. Although palonosetron is known for its safety, other hypersensitivity events have been reported. Ondansetron is another widely used 5-HT-3 antagonist, which has been reported to cause anaphylaxis. Therefore, clinicians should be aware of the possibility of patients experiencing severe adverse reactions to palonosetron. |
format | Online Article Text |
id | pubmed-5102841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-51028412017-01-01 Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report Park, Hyungjun Oh, Kyunghwan Lee, Hoonhee Lee, Ji-Hyang Kang, Sun-myoung Park, So-Young Kwon, Hyouk-Soo Cho, You Sook Moon, Hee-Bom Kim, Tae-Bum Allergy Asthma Immunol Res Case Report Palonosetron is a 5-hydroxytryptamine-3 (5-HT-3) receptor antagonist used for preventing postoperative nausea and vomiting. Compared with ondansetron and granisetron, it is a better drug because of prolonged action and minimal side effects. Some adverse effects of palonosetron have been reported. In this report, we describe a 37-year-old male who developed severe hypersensitivity reactions to palonosetron during surgery for kidney donation. His medical history was unremarkable, except for inguinal hernia with herniorrhaphy 8 years ago. The surgery was uneventful until 2 hours 20 minutes. After palonosetron injection, his blood pressure dropped to 80/50 mm Hg, and facial edema, rash, conjunctival swelling, and wheezing developed. The patient was resuscitated by administration of ephedrine, hydrocortisone, and peniramine. Following the surgery, the patient was monitored for 3 days, and there were no subsequent anaphylactic reactions or other complications. The skin test on postoperative day 54 was positive for hypersensitivity to palonosetron. Although palonosetron is known for its safety, other hypersensitivity events have been reported. Ondansetron is another widely used 5-HT-3 antagonist, which has been reported to cause anaphylaxis. Therefore, clinicians should be aware of the possibility of patients experiencing severe adverse reactions to palonosetron. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2017-01 2016-10-18 /pmc/articles/PMC5102841/ /pubmed/27826967 http://dx.doi.org/10.4168/aair.2017.9.1.92 Text en Copyright © 2016 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Park, Hyungjun Oh, Kyunghwan Lee, Hoonhee Lee, Ji-Hyang Kang, Sun-myoung Park, So-Young Kwon, Hyouk-Soo Cho, You Sook Moon, Hee-Bom Kim, Tae-Bum Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report |
title | Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report |
title_full | Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report |
title_fullStr | Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report |
title_full_unstemmed | Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report |
title_short | Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report |
title_sort | palonosetron-induced anaphylaxis during general anesthesia: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102841/ https://www.ncbi.nlm.nih.gov/pubmed/27826967 http://dx.doi.org/10.4168/aair.2017.9.1.92 |
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