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Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults

Recent evidence suggests that individual differences in physical activity (PA) may be associated with individual differences in white matter microstructure and with grey matter volume of the hippocampus. Therefore, this study investigated the association between PA and white matter microstructure of...

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Autores principales: Bracht, Tobias, Jones, Derek K., Bells, Sonya, Walther, Sebastian, Drakesmith, Mark, Linden, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102942/
https://www.ncbi.nlm.nih.gov/pubmed/26786737
http://dx.doi.org/10.1007/s00429-016-1183-3
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author Bracht, Tobias
Jones, Derek K.
Bells, Sonya
Walther, Sebastian
Drakesmith, Mark
Linden, David
author_facet Bracht, Tobias
Jones, Derek K.
Bells, Sonya
Walther, Sebastian
Drakesmith, Mark
Linden, David
author_sort Bracht, Tobias
collection PubMed
description Recent evidence suggests that individual differences in physical activity (PA) may be associated with individual differences in white matter microstructure and with grey matter volume of the hippocampus. Therefore, this study investigated the association between PA and white matter microstructure of pathways connecting to the hippocampus. A total of 33 young, healthy adults underwent magnetic resonance imaging (MRI). High angular resolution diffusion-weighted imaging and multi-component relaxometry MRI scans (multi-component driven equilibrium pulse observation of T1 and T2) were acquired for each participant. Activity levels (AL) of participants were calculated from 72-h actigraphy recordings. Tractography using the damped Richardson Lucy algorithm was used to reconstruct the fornix and bilateral parahippocampal cinguli (PHC). The mean fractional anisotropy (FA) and the myelin water fraction (MWF), a putative marker of myelination, were determined for each pathway. A positive correlation between both AL and FA and between AL and MWF were hypothesized for the three pathways. There was a selective positive correlation between AL and MWF in the right PHC (r = 0.482, p = 0.007). Thus, our results provide initial in vivo evidence for an association between myelination of the right PHC and PA in young healthy adults. Our results suggest that MWF may not only be more specific, but also more sensitive than FA to detect white matter microstructural alterations. If PA was to induce structural plasticity of the right PHC this may contribute to reverse structural alterations of the right PHC in neuropsychiatric disorder with hippocampal pathologies.
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spelling pubmed-51029422016-11-21 Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults Bracht, Tobias Jones, Derek K. Bells, Sonya Walther, Sebastian Drakesmith, Mark Linden, David Brain Struct Funct Original Article Recent evidence suggests that individual differences in physical activity (PA) may be associated with individual differences in white matter microstructure and with grey matter volume of the hippocampus. Therefore, this study investigated the association between PA and white matter microstructure of pathways connecting to the hippocampus. A total of 33 young, healthy adults underwent magnetic resonance imaging (MRI). High angular resolution diffusion-weighted imaging and multi-component relaxometry MRI scans (multi-component driven equilibrium pulse observation of T1 and T2) were acquired for each participant. Activity levels (AL) of participants were calculated from 72-h actigraphy recordings. Tractography using the damped Richardson Lucy algorithm was used to reconstruct the fornix and bilateral parahippocampal cinguli (PHC). The mean fractional anisotropy (FA) and the myelin water fraction (MWF), a putative marker of myelination, were determined for each pathway. A positive correlation between both AL and FA and between AL and MWF were hypothesized for the three pathways. There was a selective positive correlation between AL and MWF in the right PHC (r = 0.482, p = 0.007). Thus, our results provide initial in vivo evidence for an association between myelination of the right PHC and PA in young healthy adults. Our results suggest that MWF may not only be more specific, but also more sensitive than FA to detect white matter microstructural alterations. If PA was to induce structural plasticity of the right PHC this may contribute to reverse structural alterations of the right PHC in neuropsychiatric disorder with hippocampal pathologies. Springer Berlin Heidelberg 2016-01-19 2016 /pmc/articles/PMC5102942/ /pubmed/26786737 http://dx.doi.org/10.1007/s00429-016-1183-3 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Bracht, Tobias
Jones, Derek K.
Bells, Sonya
Walther, Sebastian
Drakesmith, Mark
Linden, David
Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults
title Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults
title_full Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults
title_fullStr Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults
title_full_unstemmed Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults
title_short Myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults
title_sort myelination of the right parahippocampal cingulum is associated with physical activity in young healthy adults
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102942/
https://www.ncbi.nlm.nih.gov/pubmed/26786737
http://dx.doi.org/10.1007/s00429-016-1183-3
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