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Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice
One of the hallmarks of decision-making processes is the inter-individual variability between healthy subjects. These behavioral patterns could constitute risk factors for the development of psychiatric disorders. Therefore, finding predictive markers of safe or risky decision-making is an important...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102946/ https://www.ncbi.nlm.nih.gov/pubmed/26860089 http://dx.doi.org/10.1007/s00429-016-1192-2 |
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author | Pittaras, Elsa Callebert, Jacques Chennaoui, Mounir Rabat, Arnaud Granon, Sylvie |
author_facet | Pittaras, Elsa Callebert, Jacques Chennaoui, Mounir Rabat, Arnaud Granon, Sylvie |
author_sort | Pittaras, Elsa |
collection | PubMed |
description | One of the hallmarks of decision-making processes is the inter-individual variability between healthy subjects. These behavioral patterns could constitute risk factors for the development of psychiatric disorders. Therefore, finding predictive markers of safe or risky decision-making is an important challenge for psychiatry research. We set up a mouse gambling task (MGT)—adapted from the human Iowa gambling task with uncertain contingencies between response and outcome that furthermore enables the emergence of inter-individual differences. Mice (n = 54) were further individually characterized for locomotive, emotional and cognitive behavior. Individual basal rates of monoamines and brain activation after the MGT were assessed in brain regions related to reward, emotion or cognition. In a large healthy mice population, 44 % showed a balanced strategy with limited risk-taking and flexible choices, 29 % showed a safe but rigid strategy, while 27 % adopted risky behavior. Risky mice took also more risks in other apparatus behavioral devices and were less sensitive to reward. No difference existed between groups regarding anxiety, working memory, locomotion and impulsivity. Safe/rigid mice exhibited a hypoactivation of prefrontal subareas, a high level of serotonin in the orbitofrontal cortex combined with a low level of dopamine in the putamen that predicted the emergence of rigid behavior. By contrast, high levels of dopamine, serotonin and noradrenalin in the hippocampus predicted the emergence of more exploratory and risky behaviors. The coping of C57bl/6J mice in MGT enables the determination of extreme patterns of choices either safe/rigid or risky/flexible, related to specific neurochemical and behavioral markers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1192-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5102946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-51029462016-11-21 Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice Pittaras, Elsa Callebert, Jacques Chennaoui, Mounir Rabat, Arnaud Granon, Sylvie Brain Struct Funct Original Article One of the hallmarks of decision-making processes is the inter-individual variability between healthy subjects. These behavioral patterns could constitute risk factors for the development of psychiatric disorders. Therefore, finding predictive markers of safe or risky decision-making is an important challenge for psychiatry research. We set up a mouse gambling task (MGT)—adapted from the human Iowa gambling task with uncertain contingencies between response and outcome that furthermore enables the emergence of inter-individual differences. Mice (n = 54) were further individually characterized for locomotive, emotional and cognitive behavior. Individual basal rates of monoamines and brain activation after the MGT were assessed in brain regions related to reward, emotion or cognition. In a large healthy mice population, 44 % showed a balanced strategy with limited risk-taking and flexible choices, 29 % showed a safe but rigid strategy, while 27 % adopted risky behavior. Risky mice took also more risks in other apparatus behavioral devices and were less sensitive to reward. No difference existed between groups regarding anxiety, working memory, locomotion and impulsivity. Safe/rigid mice exhibited a hypoactivation of prefrontal subareas, a high level of serotonin in the orbitofrontal cortex combined with a low level of dopamine in the putamen that predicted the emergence of rigid behavior. By contrast, high levels of dopamine, serotonin and noradrenalin in the hippocampus predicted the emergence of more exploratory and risky behaviors. The coping of C57bl/6J mice in MGT enables the determination of extreme patterns of choices either safe/rigid or risky/flexible, related to specific neurochemical and behavioral markers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00429-016-1192-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-02-10 2016 /pmc/articles/PMC5102946/ /pubmed/26860089 http://dx.doi.org/10.1007/s00429-016-1192-2 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Pittaras, Elsa Callebert, Jacques Chennaoui, Mounir Rabat, Arnaud Granon, Sylvie Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice |
title | Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice |
title_full | Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice |
title_fullStr | Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice |
title_full_unstemmed | Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice |
title_short | Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice |
title_sort | individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102946/ https://www.ncbi.nlm.nih.gov/pubmed/26860089 http://dx.doi.org/10.1007/s00429-016-1192-2 |
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