Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats

RATIONAL: Prefrontal cortical (PFC)–hippocampal–striatal circuits, interconnected via glutamatergic signaling, are dysfunctional in mental illnesses that involve addiction vulnerability. OBJECTIVES: In healthy and neurodevelopmentally altered rats, we examined how Radial Arm Maze (RAM) performance e...

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Detalles Bibliográficos
Autores principales: Rao, Kalyan N., Sentir, Alena M., Engleman, Eric A., Bell, Richard L., Hulvershorn, Leslie A., Breier, Alan, Chambers, R. Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102951/
https://www.ncbi.nlm.nih.gov/pubmed/27640177
http://dx.doi.org/10.1007/s00213-016-4421-8

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