Cargando…

Next generation sequencing of benzo(a)pyrene-induced lacZ mutants identifies a germ cell-specific mutation spectrum

De novo mutations are implicated in a variety of genetic diseases and arise primarily in the male germline. We investigated whether male germ cells have unique mechanisms for spontaneous or chemically-induced mutation relative to somatic cells using the MutaMouse model. We recovered lacZ transgenes...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Brien, Jason M., Beal, Marc A., Yauk, Carole L., Marchetti, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103183/
https://www.ncbi.nlm.nih.gov/pubmed/27829668
http://dx.doi.org/10.1038/srep36743

Ejemplares similares