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High glucose upregulates BACE1-mediated Aβ production through ROS-dependent HIF-1α and LXRα/ABCA1-regulated lipid raft reorganization in SK-N-MC cells

There is an accumulation of evidence indicating that the risk of Alzheimer’s disease is associated with diabetes mellitus, an indicator of high glucose concentrations in blood plasma. This study investigated the effect of high glucose on BACE1 expression and amyloidogenesis in vivo, and we present d...

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Detalles Bibliográficos
Autores principales:	Lee, Hyun Jik, Ryu, Jung Min, Jung, Young Hyun, Lee, Sei-Jung, Kim, Jeong Yeon, Lee, Sang Hun, Hwang, In Koo, Seong, Je Kyung, Han, Ho Jae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103190/ https://www.ncbi.nlm.nih.gov/pubmed/27829662 http://dx.doi.org/10.1038/srep36746

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