Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

Sarcopenia is associated with increased morbidity and mortality in chronic kidney disease (CKD). Pathogenic mechanism of skeletal muscle loss in CKD, which is defined as uremic sarcopenia, remains unclear. We found that causative pathological mechanism of uremic sarcopenia is metabolic alterations b...

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Detalles Bibliográficos
Autores principales: Sato, Emiko, Mori, Takefumi, Mishima, Eikan, Suzuki, Arisa, Sugawara, Sanae, Kurasawa, Naho, Saigusa, Daisuke, Miura, Daisuke, Morikawa-Ichinose, Tomomi, Saito, Ritsumi, Oba-Yabana, Ikuko, Oe, Yuji, Kisu, Kiyomi, Naganuma, Eri, Koizumi, Kenji, Mokudai, Takayuki, Niwano, Yoshimi, Kudo, Tai, Suzuki, Chitose, Takahashi, Nobuyuki, Sato, Hiroshi, Abe, Takaaki, Niwa, Toshimitsu, Ito, Sadayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103201/
https://www.ncbi.nlm.nih.gov/pubmed/27830716
http://dx.doi.org/10.1038/srep36618

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