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New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling

The PDZ domain-containing scaffold protein, syntenin-1, binds to the transmembrane proteoglycan, syndecan-4, but the molecular mechanism/function of this interaction are unknown. Crystal structure analysis of syntenin-1/syndecan-4 cytoplasmic domains revealed that syntenin-1 forms a symmetrical pair...

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Detalles Bibliográficos
Autores principales:	Choi, Youngsil, Yun, Ji-Hye, Yoo, Jiho, Lee, Inhwan, Kim, Heeyoun, Son, Hye-Nam, Kim, In-San, Yoon, Ho Sup, Zimmermann, Pascale, Couchman, John R., Cho, Hyun-Soo, Oh, Eok-Soo, Lee, Weontae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103296/ https://www.ncbi.nlm.nih.gov/pubmed/27830760 http://dx.doi.org/10.1038/srep36818

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