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Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis

Evolocumab has been considered as an efficacious, safe and promising therapeutic modality for hypercholesterolemia and is associated with cardiovascular diseases. The efficacy and safety of two different doses of evolocumab were evaluated and the safety of evolocumab was compared with that of a plac...

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Autores principales: Cheng, Cheng, Sun, Sijia, Zhou, Yafeng, Yang, Xiangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103663/
https://www.ncbi.nlm.nih.gov/pubmed/27882214
http://dx.doi.org/10.3892/br.2016.766
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author Cheng, Cheng
Sun, Sijia
Zhou, Yafeng
Yang, Xiangjun
author_facet Cheng, Cheng
Sun, Sijia
Zhou, Yafeng
Yang, Xiangjun
author_sort Cheng, Cheng
collection PubMed
description Evolocumab has been considered as an efficacious, safe and promising therapeutic modality for hypercholesterolemia and is associated with cardiovascular diseases. The efficacy and safety of two different doses of evolocumab were evaluated and the safety of evolocumab was compared with that of a placebo and ezetimibe. PubMed and EMBASE databases were searched and randomized controlled trials that examined the effect and safety of evolomucab compared with a placebo and ezetimibe were retrieved. Two authors independently performed article reviews and study quality evaluations. Odds ratios (ORs) were calculated using a fixed or random-effects model [95% confidence intervals (CIs)]. In the direct comparison, a significant reduction was observed in the muscle-associated events compared with ezetimibe [OR=0.54 (95% CI, 0.31–0.93); P (Z)=0.03, P (Q)=0.43, I(2)=0%]. In the adjusted indirect comparison of evolocumab 140 mg Q2W vs. evolocumab 420 mg Q4W, no significant differences in efficacy [OR=1.04 (95% CI, 0.55–1.99); P (Z)=0.90] or adverse events [OR=1.08 (95% CI, 0.66–1.74); P (Z)=0.76] were identified. The funnel plots of these direct comparison studies indicated that there was no publication bias. The results of this meta-analysis demonstrate that evolocumab significantly reduced low-density lipoprotein cholesterol levels, and no difference was noted between evolocumab 140 mg Q2W and evolocumab 420 mg Q4W. Furthermore, evolocumab had fewer muscle-associated events than ezetimibe.
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spelling pubmed-51036632016-11-23 Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis Cheng, Cheng Sun, Sijia Zhou, Yafeng Yang, Xiangjun Biomed Rep Articles Evolocumab has been considered as an efficacious, safe and promising therapeutic modality for hypercholesterolemia and is associated with cardiovascular diseases. The efficacy and safety of two different doses of evolocumab were evaluated and the safety of evolocumab was compared with that of a placebo and ezetimibe. PubMed and EMBASE databases were searched and randomized controlled trials that examined the effect and safety of evolomucab compared with a placebo and ezetimibe were retrieved. Two authors independently performed article reviews and study quality evaluations. Odds ratios (ORs) were calculated using a fixed or random-effects model [95% confidence intervals (CIs)]. In the direct comparison, a significant reduction was observed in the muscle-associated events compared with ezetimibe [OR=0.54 (95% CI, 0.31–0.93); P (Z)=0.03, P (Q)=0.43, I(2)=0%]. In the adjusted indirect comparison of evolocumab 140 mg Q2W vs. evolocumab 420 mg Q4W, no significant differences in efficacy [OR=1.04 (95% CI, 0.55–1.99); P (Z)=0.90] or adverse events [OR=1.08 (95% CI, 0.66–1.74); P (Z)=0.76] were identified. The funnel plots of these direct comparison studies indicated that there was no publication bias. The results of this meta-analysis demonstrate that evolocumab significantly reduced low-density lipoprotein cholesterol levels, and no difference was noted between evolocumab 140 mg Q2W and evolocumab 420 mg Q4W. Furthermore, evolocumab had fewer muscle-associated events than ezetimibe. D.A. Spandidos 2016-11 2016-09-29 /pmc/articles/PMC5103663/ /pubmed/27882214 http://dx.doi.org/10.3892/br.2016.766 Text en Copyright: © Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Cheng, Cheng
Sun, Sijia
Zhou, Yafeng
Yang, Xiangjun
Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis
title Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis
title_full Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis
title_fullStr Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis
title_full_unstemmed Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis
title_short Efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: A meta-analysis
title_sort efficacy and safety of different doses of evolocumab in reducing low-density lipoprotein cholesterol levels: a meta-analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103663/
https://www.ncbi.nlm.nih.gov/pubmed/27882214
http://dx.doi.org/10.3892/br.2016.766
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