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Debridement in chronic osteomyelitis with benign osteopetrosis: A case report
Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103689/ https://www.ncbi.nlm.nih.gov/pubmed/27882078 http://dx.doi.org/10.3892/etm.2016.3706 |
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author | Liu, Yu-Ping Lin, Xiang-Hua Yan, Man-Yun Lin, Bao-Quan Zhuo, Ming-Ying |
author_facet | Liu, Yu-Ping Lin, Xiang-Hua Yan, Man-Yun Lin, Bao-Quan Zhuo, Ming-Ying |
author_sort | Liu, Yu-Ping |
collection | PubMed |
description | Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis. The management of complications, such as chronic osteomyelitis and fractures, serves a key role in influencing the patient survival rates. Previous studies have demonstrated that a combined treatment of hyperbaric oxygen (HBO) lavage for debridement of the necrotic region and high-dose systemic antibiotics may be effective in the management of osteopetrosis. The present study reported a case of chronic mandible osteomyelitis and fistula occurring in association with maxillary sinusitis, who was successfully treated by through nasal endoscopy, using repeated flushing and cleaning every 2 weeks as a form of debridement, in the absence of high-dose antibiotics and HBO. |
format | Online Article Text |
id | pubmed-5103689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-51036892016-11-23 Debridement in chronic osteomyelitis with benign osteopetrosis: A case report Liu, Yu-Ping Lin, Xiang-Hua Yan, Man-Yun Lin, Bao-Quan Zhuo, Ming-Ying Exp Ther Med Articles Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis. The management of complications, such as chronic osteomyelitis and fractures, serves a key role in influencing the patient survival rates. Previous studies have demonstrated that a combined treatment of hyperbaric oxygen (HBO) lavage for debridement of the necrotic region and high-dose systemic antibiotics may be effective in the management of osteopetrosis. The present study reported a case of chronic mandible osteomyelitis and fistula occurring in association with maxillary sinusitis, who was successfully treated by through nasal endoscopy, using repeated flushing and cleaning every 2 weeks as a form of debridement, in the absence of high-dose antibiotics and HBO. D.A. Spandidos 2016-11 2016-09-15 /pmc/articles/PMC5103689/ /pubmed/27882078 http://dx.doi.org/10.3892/etm.2016.3706 Text en Copyright: © Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Liu, Yu-Ping Lin, Xiang-Hua Yan, Man-Yun Lin, Bao-Quan Zhuo, Ming-Ying Debridement in chronic osteomyelitis with benign osteopetrosis: A case report |
title | Debridement in chronic osteomyelitis with benign osteopetrosis: A case report |
title_full | Debridement in chronic osteomyelitis with benign osteopetrosis: A case report |
title_fullStr | Debridement in chronic osteomyelitis with benign osteopetrosis: A case report |
title_full_unstemmed | Debridement in chronic osteomyelitis with benign osteopetrosis: A case report |
title_short | Debridement in chronic osteomyelitis with benign osteopetrosis: A case report |
title_sort | debridement in chronic osteomyelitis with benign osteopetrosis: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103689/ https://www.ncbi.nlm.nih.gov/pubmed/27882078 http://dx.doi.org/10.3892/etm.2016.3706 |
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