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Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability
β-amyloid protein (Aβ) accumulation in cerebral centers involved in cognition and memory is a pivotal pathological feature of Alzheimer's disease (AD). The onset process of type 2 diabetes mellitus (T2DM) has a number of similarities compared with AD. Thus, it is hypothesized that the pharmacol...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103720/ https://www.ncbi.nlm.nih.gov/pubmed/27882091 http://dx.doi.org/10.3892/etm.2016.3742 |
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author | Wang, Xiaohui Wang, Li Jiang, Ruirui Xu, Yunyun Zhao, Xueling Li, Yang |
author_facet | Wang, Xiaohui Wang, Li Jiang, Ruirui Xu, Yunyun Zhao, Xueling Li, Yang |
author_sort | Wang, Xiaohui |
collection | PubMed |
description | β-amyloid protein (Aβ) accumulation in cerebral centers involved in cognition and memory is a pivotal pathological feature of Alzheimer's disease (AD). The onset process of type 2 diabetes mellitus (T2DM) has a number of similarities compared with AD. Thus, it is hypothesized that the pharmacological therapy employed for the treatment of T2DM may help to prevent and ameliorate the symptoms of AD. This study demonstrated that Exendin-4, which is a glucagon-like peptide-1 analogue which is used as a therapeutic drug for T2DM, markedly antagonized Aβ fragment-induced attenuation of spatial learning and memory ability, as indicated by a Morris water maze experiment. In addition, we investigated the potential underlying electrophysiological and molecular mechanisms. The results indicate that Exendin-4 rescued long-term potentiation from Aβ1-42-induced damage in the rat hippocampal CA1 region in vivo, and antagonized Aβ1-42-induced reduction of cyclic adenosine monophosphate and phosphorylated-cAMP response element-binding protein in rat hippocampal tissue using ELISA and western blot analysis, respectively. Thus, the results of the present study provide theoretical support for the application of Exendin-4 for improving AD. |
format | Online Article Text |
id | pubmed-5103720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-51037202016-11-23 Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability Wang, Xiaohui Wang, Li Jiang, Ruirui Xu, Yunyun Zhao, Xueling Li, Yang Exp Ther Med Articles β-amyloid protein (Aβ) accumulation in cerebral centers involved in cognition and memory is a pivotal pathological feature of Alzheimer's disease (AD). The onset process of type 2 diabetes mellitus (T2DM) has a number of similarities compared with AD. Thus, it is hypothesized that the pharmacological therapy employed for the treatment of T2DM may help to prevent and ameliorate the symptoms of AD. This study demonstrated that Exendin-4, which is a glucagon-like peptide-1 analogue which is used as a therapeutic drug for T2DM, markedly antagonized Aβ fragment-induced attenuation of spatial learning and memory ability, as indicated by a Morris water maze experiment. In addition, we investigated the potential underlying electrophysiological and molecular mechanisms. The results indicate that Exendin-4 rescued long-term potentiation from Aβ1-42-induced damage in the rat hippocampal CA1 region in vivo, and antagonized Aβ1-42-induced reduction of cyclic adenosine monophosphate and phosphorylated-cAMP response element-binding protein in rat hippocampal tissue using ELISA and western blot analysis, respectively. Thus, the results of the present study provide theoretical support for the application of Exendin-4 for improving AD. D.A. Spandidos 2016-11 2016-09-21 /pmc/articles/PMC5103720/ /pubmed/27882091 http://dx.doi.org/10.3892/etm.2016.3742 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wang, Xiaohui Wang, Li Jiang, Ruirui Xu, Yunyun Zhao, Xueling Li, Yang Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability |
title | Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability |
title_full | Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability |
title_fullStr | Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability |
title_full_unstemmed | Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability |
title_short | Exendin-4 antagonizes Aβ1-42-induced attenuation of spatial learning and memory ability |
title_sort | exendin-4 antagonizes aβ1-42-induced attenuation of spatial learning and memory ability |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103720/ https://www.ncbi.nlm.nih.gov/pubmed/27882091 http://dx.doi.org/10.3892/etm.2016.3742 |
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