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Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report
The present study reported the case of a Chinese boy who was diagnosed with Moyamoya disease (MMD) associated with Graves' disease (GD). An overactivation of von Willebrand factor (vWF) and coagulation factor VIII (FVIII) was identified in the plasma of the patient. Thiamazole and metoprolol tr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103767/ https://www.ncbi.nlm.nih.gov/pubmed/27882137 http://dx.doi.org/10.3892/etm.2016.3769 |
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author | Ren, Shou-Chen Gao, Bao-Qin Yang, Wei-Li Feng, Wei-Xin Xu, Jian Li, Shao-Wu Wang, Yong-Jun |
author_facet | Ren, Shou-Chen Gao, Bao-Qin Yang, Wei-Li Feng, Wei-Xin Xu, Jian Li, Shao-Wu Wang, Yong-Jun |
author_sort | Ren, Shou-Chen |
collection | PubMed |
description | The present study reported the case of a Chinese boy who was diagnosed with Moyamoya disease (MMD) associated with Graves' disease (GD). An overactivation of von Willebrand factor (vWF) and coagulation factor VIII (FVIII) was identified in the plasma of the patient. Thiamazole and metoprolol treatment was thus administrated. After 2 months of treatment, the patient's thyroid function returned to normal and the neurological symptoms improved gradually. At the same time, the activities of vWF and FVIII were depressed. During the 20-month follow-up, information regarding the neurological symptoms, cerebrovascular imaging, thyroid function, thyroid autoantibodies and coagulation parameters was collected. High levels of thyroid autoantibodies persisted throughout the follow-up period, while other coagulation parameters remained in the normal range. In conclusion, considering the vital role of vWF and FVIII in vascular diseases, it is hypothesized that these two factors may serve an important role in the occurrence of GD associated with MMD. |
format | Online Article Text |
id | pubmed-5103767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-51037672016-11-23 Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report Ren, Shou-Chen Gao, Bao-Qin Yang, Wei-Li Feng, Wei-Xin Xu, Jian Li, Shao-Wu Wang, Yong-Jun Exp Ther Med Articles The present study reported the case of a Chinese boy who was diagnosed with Moyamoya disease (MMD) associated with Graves' disease (GD). An overactivation of von Willebrand factor (vWF) and coagulation factor VIII (FVIII) was identified in the plasma of the patient. Thiamazole and metoprolol treatment was thus administrated. After 2 months of treatment, the patient's thyroid function returned to normal and the neurological symptoms improved gradually. At the same time, the activities of vWF and FVIII were depressed. During the 20-month follow-up, information regarding the neurological symptoms, cerebrovascular imaging, thyroid function, thyroid autoantibodies and coagulation parameters was collected. High levels of thyroid autoantibodies persisted throughout the follow-up period, while other coagulation parameters remained in the normal range. In conclusion, considering the vital role of vWF and FVIII in vascular diseases, it is hypothesized that these two factors may serve an important role in the occurrence of GD associated with MMD. D.A. Spandidos 2016-11 2016-10-03 /pmc/articles/PMC5103767/ /pubmed/27882137 http://dx.doi.org/10.3892/etm.2016.3769 Text en Copyright: © Ren et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Ren, Shou-Chen Gao, Bao-Qin Yang, Wei-Li Feng, Wei-Xin Xu, Jian Li, Shao-Wu Wang, Yong-Jun Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report |
title | Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report |
title_full | Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report |
title_fullStr | Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report |
title_full_unstemmed | Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report |
title_short | Von Willebrand factor and coagulation factor VIII in Moyamoya disease associated with Graves' disease: A case report |
title_sort | von willebrand factor and coagulation factor viii in moyamoya disease associated with graves' disease: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103767/ https://www.ncbi.nlm.nih.gov/pubmed/27882137 http://dx.doi.org/10.3892/etm.2016.3769 |
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