Cargando…
mTOR downstream effectors, 4EBP1 and eIF4E, are overexpressed and associated with HPV status in precancerous lesions and carcinomas of the uterine cervix
The present study aims to investigate the expression levels of two critical mammalian target of rapamycin (mTOR) downstream effectors, 4E binding protein 1 (4EBP1) and eukaryotic initiation factor 4E (eIF4E) proteins, in precancerous squamous intraepithelial lesions and cancer of the uterine cervix,...
Autores principales: | Asimomytis, Aristidis, Karanikou, Maria, Rodolakis, Alexander, Vaiopoulou, Anna, Tsetsa, Paraskevi, Creatsas, George, Stefos, Theodoros, Antsaklis, Aristidis, Patsouris, Efstratios, Rassidakis, George Z. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103924/ https://www.ncbi.nlm.nih.gov/pubmed/27899988 http://dx.doi.org/10.3892/ol.2016.5056 |
Ejemplares similares
-
Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling
por: Shen, Peng, et al.
Publicado: (2018) -
The eIF4EBP-eIF4E axis regulates CD4(+) T cell differentiation through modulation of T cell activation and metabolism
por: Istomine, Roman, et al.
Publicado: (2023) -
Synergistic activation of eIF4A by eIF4B and eIF4G
por: Nielsen, Klaus H., et al.
Publicado: (2011) -
BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma
por: Wan, Pei, et al.
Publicado: (2020) -
eIF4E3 forms an active eIF4F complex during stresses (eIF4F(S)) targeting mTOR and re-programs the translatome
por: Weiss, Benjamin, et al.
Publicado: (2021)