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APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer

Lung cancer is the leading cause of cancer-associated mortality. Non-small cell lung cancer (NSCLC) accounts for >80% of lung cancers. The overall survival for NSCLC is dismal, with a 5-year survival of <5% for patients. Thus, identifying an effective biomarker for early diagnosis of lung canc...

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Autores principales: Dou, Hengli, Yan, Zhaohua, Zhang, Meng, Xu, Xiaoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103951/
https://www.ncbi.nlm.nih.gov/pubmed/27900003
http://dx.doi.org/10.3892/ol.2016.5095
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author Dou, Hengli
Yan, Zhaohua
Zhang, Meng
Xu, Xiaoxin
author_facet Dou, Hengli
Yan, Zhaohua
Zhang, Meng
Xu, Xiaoxin
author_sort Dou, Hengli
collection PubMed
description Lung cancer is the leading cause of cancer-associated mortality. Non-small cell lung cancer (NSCLC) accounts for >80% of lung cancers. The overall survival for NSCLC is dismal, with a 5-year survival of <5% for patients. Thus, identifying an effective biomarker for early diagnosis of lung cancer is the first essential step to reduce mortality. It has been recognized that certain inflammatory and immune responses are important in lung cancer development and prevention. The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells. Overall, the present study provides evidence that APRIL and its receptors, BCMA and TACI, may play roles in the biological processes of NSCLC tumors through the ERK1/2 signaling pathway.
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spelling pubmed-51039512016-11-29 APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer Dou, Hengli Yan, Zhaohua Zhang, Meng Xu, Xiaoxin Oncol Lett Articles Lung cancer is the leading cause of cancer-associated mortality. Non-small cell lung cancer (NSCLC) accounts for >80% of lung cancers. The overall survival for NSCLC is dismal, with a 5-year survival of <5% for patients. Thus, identifying an effective biomarker for early diagnosis of lung cancer is the first essential step to reduce mortality. It has been recognized that certain inflammatory and immune responses are important in lung cancer development and prevention. The present study demonstrated that, in NSCLC, a proliferation-inducing ligand (APRIL), B-cell maturation antigen (BCMA)and transmembrane activator and CAML interactor (TACI) proteins are abnormally expressed by immunohistochemistry, reverse transcription-quantitative polymerase chain reaction and western blotting. In addition, the expression of APRIL, BCMA and TACI were observed to be involved in extracellular signal-regulated kinase (ERK)1/2 activation in A549 cells. Overall, the present study provides evidence that APRIL and its receptors, BCMA and TACI, may play roles in the biological processes of NSCLC tumors through the ERK1/2 signaling pathway. D.A. Spandidos 2016-11 2016-09-06 /pmc/articles/PMC5103951/ /pubmed/27900003 http://dx.doi.org/10.3892/ol.2016.5095 Text en Copyright: © Dou et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Dou, Hengli
Yan, Zhaohua
Zhang, Meng
Xu, Xiaoxin
APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer
title APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer
title_full APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer
title_fullStr APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer
title_full_unstemmed APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer
title_short APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer
title_sort april, bcma and taci proteins are abnormally expressed in non-small cell lung cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103951/
https://www.ncbi.nlm.nih.gov/pubmed/27900003
http://dx.doi.org/10.3892/ol.2016.5095
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