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Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis
OBJECTIVES: It has been reported that low skeletal muscle mass correlates with knee osteoarthritis in obese individuals. This study aimed to investigate whether lower limb skeletal muscle mass is independently associated with knee osteoarthritis in the general population. MATERIALS AND METHODS: This...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104343/ https://www.ncbi.nlm.nih.gov/pubmed/27832208 http://dx.doi.org/10.1371/journal.pone.0166385 |
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author | Lee, Sang Yoon Ro, Hee Joon Chung, Sun G. Kang, Si Hyun Seo, Kyung Mook Kim, Don-Kyu |
author_facet | Lee, Sang Yoon Ro, Hee Joon Chung, Sun G. Kang, Si Hyun Seo, Kyung Mook Kim, Don-Kyu |
author_sort | Lee, Sang Yoon |
collection | PubMed |
description | OBJECTIVES: It has been reported that low skeletal muscle mass correlates with knee osteoarthritis in obese individuals. This study aimed to investigate whether lower limb skeletal muscle mass is independently associated with knee osteoarthritis in the general population. MATERIALS AND METHODS: This cross-sectional study used public data from the Fourth and Fifth Korean National Health and Nutrition Examination Survey. Subjects included 4924 community-dwelling adults aged ≥50 years (821 subjects with knee osteoarthritis and 4,103 controls). Skeletal muscle mass index (SMI) was calculated from the appendicular skeletal muscle mass measured by dual energy X-ray absorptiometry. Independent effects of total and lower limb SMI values on knee osteoarthritis were determined using odds ratios (OR) adjusted for age, sex, obesity, total femur bone mineral density, serum vitamin D level, diabetes mellitus status, and physical activity on multivariate logistic regression analysis. RESULTS: The adjusted logistic regression model revealed that older age, female sex, and obesity were significantly associated with knee osteoarthritis. A higher serum vitamin D level was also positively correlated with knee osteoarthritis (OR, 1.015; 95% CI, 1.003–1.027; P = 0.010). Although total SMI was not significantly associated with knee osteoarthritis (OR, 0.976; 95% CI, 0.946–1.007; P = 0.127), a low lower limb SMI had an independent effect on knee osteoarthritis (OR, 0.941; 95% CI, 0.900–0.983; P = 0.006). CONCLUSIONS: Low skeletal muscle mass in the lower limbs but not in the whole body was independently associated with knee osteoarthritis. |
format | Online Article Text |
id | pubmed-5104343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-51043432016-12-08 Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis Lee, Sang Yoon Ro, Hee Joon Chung, Sun G. Kang, Si Hyun Seo, Kyung Mook Kim, Don-Kyu PLoS One Research Article OBJECTIVES: It has been reported that low skeletal muscle mass correlates with knee osteoarthritis in obese individuals. This study aimed to investigate whether lower limb skeletal muscle mass is independently associated with knee osteoarthritis in the general population. MATERIALS AND METHODS: This cross-sectional study used public data from the Fourth and Fifth Korean National Health and Nutrition Examination Survey. Subjects included 4924 community-dwelling adults aged ≥50 years (821 subjects with knee osteoarthritis and 4,103 controls). Skeletal muscle mass index (SMI) was calculated from the appendicular skeletal muscle mass measured by dual energy X-ray absorptiometry. Independent effects of total and lower limb SMI values on knee osteoarthritis were determined using odds ratios (OR) adjusted for age, sex, obesity, total femur bone mineral density, serum vitamin D level, diabetes mellitus status, and physical activity on multivariate logistic regression analysis. RESULTS: The adjusted logistic regression model revealed that older age, female sex, and obesity were significantly associated with knee osteoarthritis. A higher serum vitamin D level was also positively correlated with knee osteoarthritis (OR, 1.015; 95% CI, 1.003–1.027; P = 0.010). Although total SMI was not significantly associated with knee osteoarthritis (OR, 0.976; 95% CI, 0.946–1.007; P = 0.127), a low lower limb SMI had an independent effect on knee osteoarthritis (OR, 0.941; 95% CI, 0.900–0.983; P = 0.006). CONCLUSIONS: Low skeletal muscle mass in the lower limbs but not in the whole body was independently associated with knee osteoarthritis. Public Library of Science 2016-11-10 /pmc/articles/PMC5104343/ /pubmed/27832208 http://dx.doi.org/10.1371/journal.pone.0166385 Text en © 2016 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lee, Sang Yoon Ro, Hee Joon Chung, Sun G. Kang, Si Hyun Seo, Kyung Mook Kim, Don-Kyu Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis |
title | Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis |
title_full | Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis |
title_fullStr | Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis |
title_full_unstemmed | Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis |
title_short | Low Skeletal Muscle Mass in the Lower Limbs Is Independently Associated to Knee Osteoarthritis |
title_sort | low skeletal muscle mass in the lower limbs is independently associated to knee osteoarthritis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104343/ https://www.ncbi.nlm.nih.gov/pubmed/27832208 http://dx.doi.org/10.1371/journal.pone.0166385 |
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