The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments

BACKGROUND: In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca(2+) transients, cell shortening and in experimental arrhythmias. The level of selectivity of the novel inhibitor on several major transmem...

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Detalles Bibliográficos
Autores principales: Kohajda, Zsófia, Farkas-Morvay, Nikolett, Jost, Norbert, Nagy, Norbert, Geramipour, Amir, Horváth, András, Varga, Richárd S., Hornyik, Tibor, Corici, Claudia, Acsai, Károly, Horváth, Balázs, Prorok, János, Ördög, Balázs, Déri, Szilvia, Tóth, Dániel, Levijoki, Jouko, Pollesello, Piero, Koskelainen, Tuula, Otsomaa, Leena, Tóth, András, Baczkó, István, Leprán, István, Nánási, Péter P., Papp, Julius Gy, Varró, András, Virág, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104402/
https://www.ncbi.nlm.nih.gov/pubmed/27832106
http://dx.doi.org/10.1371/journal.pone.0166041

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