A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice

Obesity is now recognized as a state of chronic low-grade inflammation and is called as metabolic inflammation. Delta-5 desaturase (D5D) is an enzyme that metabolizes dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA). Thus, D5D inhibition increases DGLA (precursor to anti-inflammatory eicosano...

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Detalles Bibliográficos
Autores principales: Yashiro, Hiroaki, Takagahara, Shuichi, Tamura, Yumiko Okano, Miyahisa, Ikuo, Matsui, Junji, Suzuki, Hideo, Ikeda, Shota, Watanabe, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104425/
https://www.ncbi.nlm.nih.gov/pubmed/27832159
http://dx.doi.org/10.1371/journal.pone.0166198

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