Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations

BACKGROUND: Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. OBJECTIVE: We examined multiple properties of LRRK2 behavior in cellular models over-expressing three sequen...

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Detalles Bibliográficos
Autores principales: Melachroinou, Katerina, Leandrou, Emmanouela, Valkimadi, Polytimi-Eleni, Memou, Anna, Hadjigeorgiou, Georgios, Stefanis, Leonidas, Rideout, Hardy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104429/
https://www.ncbi.nlm.nih.gov/pubmed/27832104
http://dx.doi.org/10.1371/journal.pone.0166053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104429/
https://www.ncbi.nlm.nih.gov/pubmed/27832104
http://dx.doi.org/10.1371/journal.pone.0166053

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