ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for triggering necroptosis but not for triggering apoptosis, which makes it a unique target for pharmacological inhibition to block necroptotic c...

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Detalles Bibliográficos
Autores principales: Ma, Bin, Marcotte, Doug, Paramasivam, Murugan, Michelsen, Klaus, Wang, Ti, Bertolotti-Ciarlet, Andrea, Jones, John Howard, Moree, Ben, Butko, Margaret, Salafsky, Joshua, Sun, Xin, McKee, Timothy, Silvian, Laura F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104457/
https://www.ncbi.nlm.nih.gov/pubmed/27832137
http://dx.doi.org/10.1371/journal.pone.0165983

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