The Salmonella Effector SteD Mediates MARCH8-Dependent Ubiquitination of MHC II Molecules and Inhibits T Cell Activation

The SPI-2 type III secretion system (T3SS) of intracellular Salmonella enterica translocates effector proteins into mammalian cells. Infection of antigen-presenting cells results in SPI-2 T3SS-dependent ubiquitination and reduction of surface-localized mature MHC class II (mMHCII). We identify the e...

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Detalles Bibliográficos
Autores principales: Bayer-Santos, Ethel, Durkin, Charlotte H., Rigano, Luciano A., Kupz, Andreas, Alix, Eric, Cerny, Ondrej, Jennings, Elliott, Liu, Mei, Ryan, Aindrias S., Lapaque, Nicolas, Kaufmann, Stefan H.E., Holden, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104694/
https://www.ncbi.nlm.nih.gov/pubmed/27832589
http://dx.doi.org/10.1016/j.chom.2016.10.007

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