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Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer

The leading cause of drug-induced liver injury in the developed world is overdose with N-acetyl-p-aminophenol (APAP). A comparative metabonomic approach was applied to the study of both xenobiotic and endogenous metabolic profiles reflective of in vivo exposure to APAP (300 mg/kg) and its structural...

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Detalles Bibliográficos
Autores principales:	Kyriakides, Michael, Maitre, Lea, Stamper, Brendan D., Mohar, Isaac, Kavanagh, Terrance J., Foster, John, Wilson, Ian D., Holmes, Elaine, Nelson, Sidney D., Coen, Muireann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104807/ https://www.ncbi.nlm.nih.gov/pubmed/26746206 http://dx.doi.org/10.1007/s00204-015-1655-x

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