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Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report

The purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate. Numb chin syndrome (NCS), which was associated with this case, is also discussed. Computed tomography (CT) and an intraoral incisional biopsy of the left mandibular...

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Autores principales: Kim, Il-Kyu, Lee, Dong-Hwan, Cho, Hyun-Young, Seo, Ji-Hoon, Park, Seung-Hoon, Kim, Joon-Mee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Oral and Maxillofacial Surgeons 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104874/
https://www.ncbi.nlm.nih.gov/pubmed/27847740
http://dx.doi.org/10.5125/jkaoms.2016.42.5.301
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author Kim, Il-Kyu
Lee, Dong-Hwan
Cho, Hyun-Young
Seo, Ji-Hoon
Park, Seung-Hoon
Kim, Joon-Mee
author_facet Kim, Il-Kyu
Lee, Dong-Hwan
Cho, Hyun-Young
Seo, Ji-Hoon
Park, Seung-Hoon
Kim, Joon-Mee
author_sort Kim, Il-Kyu
collection PubMed
description The purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate. Numb chin syndrome (NCS), which was associated with this case, is also discussed. Computed tomography (CT) and an intraoral incisional biopsy of the left mandibular area were performed. Urology consultation, hormone therapy, chemotherapy and follow-up radiographic images were administered. Histological examination of the incised specimen revealed moderately differentiated adenocarcinoma. The Gleason score was 8 (primary 4/secondary 4). Immunohistochemical features and radiographic results confirmed the diagnosis of metastasis from prostate adenocarcinoma, moderately differentiated. The patient's prostate-specific antigen (PSA) level was very high. After hormone treatment, the patient's PSA levels dropped gradually. Seventeen months later, in May 2015, the PSA level was elevated. The 18-month follow-up CT image indicated that the patient's condition was aggravated. Docetaxel chemotherapy was started in June 2015 (18 months later), and the sixth cycle of the therapy is in progress. Oral metastases that originate from prostate adenocarcinoma are rare and can induce various periosteal reactions. Hormone therapy, chemotherapy and close follow-up could be additional, appropriate treatment, and were applied in this case. Finally, NCS is a valuable indicator of metastatic disease in the mandible.
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spelling pubmed-51048742016-11-15 Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report Kim, Il-Kyu Lee, Dong-Hwan Cho, Hyun-Young Seo, Ji-Hoon Park, Seung-Hoon Kim, Joon-Mee J Korean Assoc Oral Maxillofac Surg Case Report The purpose of this study is to report a rare case of mandibular adenocarcinoma that was diagnosed due to metastasis from the prostate. Numb chin syndrome (NCS), which was associated with this case, is also discussed. Computed tomography (CT) and an intraoral incisional biopsy of the left mandibular area were performed. Urology consultation, hormone therapy, chemotherapy and follow-up radiographic images were administered. Histological examination of the incised specimen revealed moderately differentiated adenocarcinoma. The Gleason score was 8 (primary 4/secondary 4). Immunohistochemical features and radiographic results confirmed the diagnosis of metastasis from prostate adenocarcinoma, moderately differentiated. The patient's prostate-specific antigen (PSA) level was very high. After hormone treatment, the patient's PSA levels dropped gradually. Seventeen months later, in May 2015, the PSA level was elevated. The 18-month follow-up CT image indicated that the patient's condition was aggravated. Docetaxel chemotherapy was started in June 2015 (18 months later), and the sixth cycle of the therapy is in progress. Oral metastases that originate from prostate adenocarcinoma are rare and can induce various periosteal reactions. Hormone therapy, chemotherapy and close follow-up could be additional, appropriate treatment, and were applied in this case. Finally, NCS is a valuable indicator of metastatic disease in the mandible. The Korean Association of Oral and Maxillofacial Surgeons 2016-10 2016-10-25 /pmc/articles/PMC5104874/ /pubmed/27847740 http://dx.doi.org/10.5125/jkaoms.2016.42.5.301 Text en Copyright © 2016 The Korean Association of Oral and Maxillofacial Surgeons. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Il-Kyu
Lee, Dong-Hwan
Cho, Hyun-Young
Seo, Ji-Hoon
Park, Seung-Hoon
Kim, Joon-Mee
Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
title Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
title_full Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
title_fullStr Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
title_full_unstemmed Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
title_short Prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
title_sort prostate adenocarcinoma mandibular metastasis associated with numb chin syndrome: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104874/
https://www.ncbi.nlm.nih.gov/pubmed/27847740
http://dx.doi.org/10.5125/jkaoms.2016.42.5.301
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