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Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq

Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF(580), GEFT and a recently discovered longer isoform of 619 amino acids (p6...

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Detalles Bibliográficos
Autores principales:	van Unen, Jakobus, Yin, Taofei, Wu, Yi I., Mastop, Marieke, Gadella, Theodorus W. J., Goedhart, Joachim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105084/ https://www.ncbi.nlm.nih.gov/pubmed/27833100 http://dx.doi.org/10.1038/srep36825

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