Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015

The prevalence of HBV DNA among seronegative blood donations in China has not been studied extensively on a nationwide scale. The aim of this study was to analyse the prevalence, trend, distributions, and serological characteristics of HBV DNA positive/seronegative blood donations. We collected HBV...

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Autores principales: Liu, Chao, Chang, Le, Ji, Huimin, Guo, Fei, Zhang, Kuo, Lin, Guigao, Zhang, Rui, Li, Jinming, Wang, Lunan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105122/
https://www.ncbi.nlm.nih.gov/pubmed/27833112
http://dx.doi.org/10.1038/srep36464
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author Liu, Chao
Chang, Le
Ji, Huimin
Guo, Fei
Zhang, Kuo
Lin, Guigao
Zhang, Rui
Li, Jinming
Wang, Lunan
author_facet Liu, Chao
Chang, Le
Ji, Huimin
Guo, Fei
Zhang, Kuo
Lin, Guigao
Zhang, Rui
Li, Jinming
Wang, Lunan
author_sort Liu, Chao
collection PubMed
description The prevalence of HBV DNA among seronegative blood donations in China has not been studied extensively on a nationwide scale. The aim of this study was to analyse the prevalence, trend, distributions, and serological characteristics of HBV DNA positive/seronegative blood donations. We collected HBV test data from all blood banks of China from 2010 to 2015 and performed supplemental serological tests and quantitative detection of HBV DNA of the seronegative/HBV DNA positive blood donations. We analysed the prevalence of HBV DNA among seronegative blood donations screened by varying nucleotide acid test (NAT) reagents. The analysis results showed that a total of 20,084,187 seronegative blood donations were screened by NAT from 2010 to 2015 in China. The average frequency of HBV DNA among seronegative blood donations was 1/1482, but there has been a steady increase from 1/1861 in 2011 to 1/1269 in 2015. The geographical distribution of seronegative and HBV DNA positive blood donations was roughly consistent with that of HBsAg. The most common serological pattern was HBeAb and HBcAb positive. In conclusion, our study offeres fundamental data of seronegative and HBV DNA positive blood donations throughout China.
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spelling pubmed-51051222016-11-17 Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015 Liu, Chao Chang, Le Ji, Huimin Guo, Fei Zhang, Kuo Lin, Guigao Zhang, Rui Li, Jinming Wang, Lunan Sci Rep Article The prevalence of HBV DNA among seronegative blood donations in China has not been studied extensively on a nationwide scale. The aim of this study was to analyse the prevalence, trend, distributions, and serological characteristics of HBV DNA positive/seronegative blood donations. We collected HBV test data from all blood banks of China from 2010 to 2015 and performed supplemental serological tests and quantitative detection of HBV DNA of the seronegative/HBV DNA positive blood donations. We analysed the prevalence of HBV DNA among seronegative blood donations screened by varying nucleotide acid test (NAT) reagents. The analysis results showed that a total of 20,084,187 seronegative blood donations were screened by NAT from 2010 to 2015 in China. The average frequency of HBV DNA among seronegative blood donations was 1/1482, but there has been a steady increase from 1/1861 in 2011 to 1/1269 in 2015. The geographical distribution of seronegative and HBV DNA positive blood donations was roughly consistent with that of HBsAg. The most common serological pattern was HBeAb and HBcAb positive. In conclusion, our study offeres fundamental data of seronegative and HBV DNA positive blood donations throughout China. Nature Publishing Group 2016-11-11 /pmc/articles/PMC5105122/ /pubmed/27833112 http://dx.doi.org/10.1038/srep36464 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liu, Chao
Chang, Le
Ji, Huimin
Guo, Fei
Zhang, Kuo
Lin, Guigao
Zhang, Rui
Li, Jinming
Wang, Lunan
Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015
title Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015
title_full Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015
title_fullStr Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015
title_full_unstemmed Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015
title_short Prevalence of HBV DNA among 20 million seronegative blood donations in China from 2010 to 2015
title_sort prevalence of hbv dna among 20 million seronegative blood donations in china from 2010 to 2015
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105122/
https://www.ncbi.nlm.nih.gov/pubmed/27833112
http://dx.doi.org/10.1038/srep36464
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