Cargando…

Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase

CAG/CTG repeat expansions cause over 13 neurological diseases that remain without a cure. Because longer tracts cause more severe phenotypes, contracting them may provide a therapeutic avenue. No currently known agent can specifically generate contractions. Using a GFP-based chromosomal reporter tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cinesi, Cinzia, Aeschbach, Lorène, Yang, Bin, Dion, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105158/ https://www.ncbi.nlm.nih.gov/pubmed/27827362 http://dx.doi.org/10.1038/ncomms13272

Ejemplares similares

Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing
por: Yang, Bin, et al.
Publicado: (2021)

Minimizing carry-over PCR contamination in expanded CAG/CTG repeat instability applications
por: Aeschbach, Lorène, et al.
Publicado: (2017)

Modifiers of CAG/CTG Repeat Instability: Insights from Mammalian Models
por: Wheeler, Vanessa C., et al.
Publicado: (2021)

Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases
por: Dabrowska, Magdalena, et al.
Publicado: (2018)

CRISPR/Cas9-Induced (CTG⋅CAG)(n) Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing
por: van Agtmaal, Ellen L., et al.
Publicado: (2017)

Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast
por: Richard, Guy-Franck, et al.
Publicado: (2014)

CAG·CTG repeat instability in cultured human astrocytes
por: Farrell, Brian T., et al.
Publicado: (2006)

Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion
por: Ruiz Buendía, Gustavo A., et al.
Publicado: (2020)

Target-dependent nickase activities of CRISPR-Cas nucleases Cpf1 and Cas9
por: Hua Fu, Becky Xu, et al.
Publicado: (2019)

Mechanistic features of CAG•CTG repeat contractions in cultured cells revealed by a novel genetic assay
por: Pelletier, Richard, et al.
Publicado: (2005)

Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach
por: Ikeda, Miki, et al.
Publicado: (2020)

Length-dependent energetics of (CTG)(n) and (CAG)(n) trinucleotide repeats
por: Amrane, Samir, et al.
Publicado: (2005)

Replication dependent instability at (CTG)•(CAG) repeat hairpins in human cells
por: Liu, Guoqi, et al.
Publicado: (2010)

Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis
por: Liu, Guoqi, et al.
Publicado: (2012)

Triptycene-based small molecules modulate (CAG)·(CTG) repeat junctions
por: Barros, Stephanie A., et al.
Publicado: (2015)

Time-controlled and muscle-specific CRISPR/Cas9-mediated deletion of CTG-repeat expansion in the DMPK gene
por: Cardinali, Beatrice, et al.
Publicado: (2021)

Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells
por: Nakatani, Rie, et al.
Publicado: (2015)

Performance of the Cas9 Nickase System in Drosophila melanogaster
por: Ren, Xingjie, et al.
Publicado: (2014)

Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
por: Ye, Tao, et al.
Publicado: (2021)

Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks
por: Polleys, Erica J., et al.
Publicado: (2023)

CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X
por: Karimova, Madina, et al.
Publicado: (2015)

CRISPR/Cas9 nickase mediated targeting of urokinase receptor gene inhibits neuroblastoma cell proliferation
por: Rysenkova, Karina D., et al.
Publicado: (2018)

Efficient Homologous Recombination in Mice Using Long Single Stranded DNA and CRISPR Cas9 Nickase
por: Ge, Xi A., et al.
Publicado: (2018)

Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability
por: Reddy, Kaalak, et al.
Publicado: (2014)

The role of break-induced replication in large-scale expansions of (CAG)(n)•(CTG)(n) repeats
por: Kim, Jane C., et al.
Publicado: (2016)

MSH2 ATPase Domain Mutation Affects CTG•CAG Repeat Instability in Transgenic Mice
por: Tomé, Stéphanie, et al.
Publicado: (2009)

Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats
por: Ma, Long, et al.
Publicado: (2013)

CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing
por: Chiang, Ting-Wei Will, et al.
Publicado: (2016)

SWISS: multiplexed orthogonal genome editing in plants with a Cas9 nickase and engineered CRISPR RNA scaffolds
por: Li, Chao, et al.
Publicado: (2020)

Utilization of the CRISPR/Cas9 system for the efficient production of mutant mice using crRNA/tracrRNA with Cas9 nickase and FokI-dCas9
por: Terao, Miho, et al.
Publicado: (2016)

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
por: Cho, Seung Woo, et al.
Publicado: (2014)

Precision Targeted Mutagenesis via Cas9 Paired Nickases in Rice
por: Mikami, Masafumi, et al.
Publicado: (2016)

Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9
por: Kurihara, Takeshi, et al.
Publicado: (2017)

Prime editing with genuine Cas9 nickases minimizes unwanted indels
por: Lee, Jaesuk, et al.
Publicado: (2023)

The Convenience of Single Homology Arm Donor DNA and CRISPR/Cas9-Nickase for Targeted Insertion of Long DNA Fragment
por: Basiri, Mohsen, et al.
Publicado: (2017)

Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template
por: Rong, Zhili, et al.
Publicado: (2014)

Paired CRISPR/Cas9 Nickases Mediate Efficient Site-Specific Integration of F9 into rDNA Locus of Mouse ESCs
por: Wang, Yanchi, et al.
Publicado: (2018)

FAN1-MLH1 interaction affects repair of DNA interstrand cross-links and slipped-CAG/CTG repeats
por: Porro, Antonio, et al.
Publicado: (2021)

Oxidized dNTPs and the OGG1 and MUTYH DNA glycosylases combine to induce CAG/CTG repeat instability
por: Cilli, Piera, et al.
Publicado: (2016)

Expanded CAG/CTG Repeat DNA Induces a Checkpoint Response That Impacts Cell Proliferation in Saccharomyces cerevisiae
por: Sundararajan, Rangapriya, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_svlnu770cftkq2mgqa7mkqfmd2