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MHC class II complexes sample intermediate states along the peptide exchange pathway

The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-known immunological concept in vertebrates, yet the conformational dynamics of antigen exchange remain elusive. By combining NMR-detected H/D exchange with Markov modelling analysis of an aggregate of 275 mic...

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Detalles Bibliográficos
Autores principales:	Wieczorek, Marek, Sticht, Jana, Stolzenberg, Sebastian, Günther, Sebastian, Wehmeyer, Christoph, El Habre, Zeina, Álvaro-Benito, Miguel, Noé, Frank, Freund, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105163/ https://www.ncbi.nlm.nih.gov/pubmed/27827392 http://dx.doi.org/10.1038/ncomms13224

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