Cargando…

Control of diabetic hyperglycaemia and insulin resistance through TSC22D4

Obesity-related insulin resistance represents the core component of the metabolic syndrome, promoting glucose intolerance, pancreatic beta cell failure and type 2 diabetes. Efficient and safe insulin sensitization and glucose control remain critical therapeutic aims to prevent diabetic late complica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ekim Üstünel, Bilgen, Friedrich, Kilian, Maida, Adriano, Wang, Xiaoyue, Krones-Herzig, Anja, Seibert, Oksana, Sommerfeld, Anke, Jones, Allan, Sijmonsma, Tjeerd P., Sticht, Carsten, Gretz, Norbert, Fleming, Thomas, Nawroth, Peter P., Stremmel, Wolfgang, Rose, Adam J., Berriel-Diaz, Mauricio, Blüher, Matthias, Herzig, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105165/ https://www.ncbi.nlm.nih.gov/pubmed/27827363 http://dx.doi.org/10.1038/ncomms13267

Ejemplares similares

TSC22D4 is a molecular output of hepatic wasting metabolism
por: Jones, Allan, et al.
Publicado: (2013)

TSC22D4 interacts with Akt1 to regulate glucose metabolism
por: Demir, Sevgican, et al.
Publicado: (2022)

Emerging Targets in Type 2 Diabetes and Diabetic Complications
por: Demir, Sevgican, et al.
Publicado: (2021)

Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health
por: Fuhrmeister, Jessica, et al.
Publicado: (2016)

Brown Adipose Tissue Harbors a Distinct Sub-Population of Regulatory T Cells
por: Medrikova, Dasa, et al.
Publicado: (2015)

Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function
por: Wolff, Gretchen, et al.
Publicado: (2022)

A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice
por: Wortmann, Markus, et al.
Publicado: (2016)

Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control
por: Bühler, Lea, et al.
Publicado: (2021)

Liver-Specific Loss of Lipolysis-Stimulated Lipoprotein Receptor Triggers Systemic Hyperlipidemia in Mice
por: Narvekar, Prachiti, et al.
Publicado: (2009)

Browning of White Adipose Tissue Uncouples Glucose Uptake from Insulin Signaling
por: Mössenböck, Karin, et al.
Publicado: (2014)

Endothelial Notch signaling controls insulin transport in muscle
por: Hasan, Sana S, et al.
Publicado: (2020)

PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis
por: Cheng, Yong-Sheng, et al.
Publicado: (2015)

Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy
por: Stoy, Christian, et al.
Publicado: (2015)

Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans
por: Lou, Bowen, et al.
Publicado: (2020)

Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
por: Jiang, Yang, et al.
Publicado: (2015)

FOXO3 Is a Glucocorticoid Receptor Target and Regulates LKB1 and Its Own Expression Based on Cellular AMP Levels via a Positive Autoregulatory Loop
por: Lützner, Nicolas, et al.
Publicado: (2012)

Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases
por: Pellegata, Natalia S., et al.
Publicado: (2022)

Molecular regulation of urea cycle function by the liver glucocorticoid receptor
por: Okun, Jürgen G., et al.
Publicado: (2015)

Corrigendum to “Molecular regulation of urea cycle function by the liver glucocorticoid receptor” [Mol Metab 4 (10) (2015 Oct) 732–740]
por: Okun, Jürgen G., et al.
Publicado: (2020)

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention
por: Brings, Sebastian, et al.
Publicado: (2017)

Diabetic Pneumopathy–A New Diabetes-Associated Complication: Mechanisms, Consequences and Treatment Considerations
por: Kopf, Stefan, et al.
Publicado: (2021)

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
por: Hoogeveen-Westerveld, Marianne, et al.
Publicado: (2012)

Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
por: Tyburczy, Magdalena E., et al.
Publicado: (2015)

Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2
por: Kwiatkowski, David J, et al.
Publicado: (2015)

Evidence for population variation in TSC1 and TSC2 gene expression
por: Jentarra, Garilyn M, et al.
Publicado: (2011)

Hyperglycaemia and cancer risk
por: Asp, Nils-Georg
Publicado: (2007)

Analysis of the TSC1and TSC2genes in sporadic renal cell carcinomas
por: Parry, L, et al.
Publicado: (2001)

Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
por: Liu, Jie, et al.
Publicado: (2019)

Imaging modalities for diagnosis and monitoring of cancer cachexia
por: Han, Jessie, et al.
Publicado: (2021)

In-Silico Algorithms for the Screening of Possible microRNA Binding Sites and Their Interactions
por: Dweep, Harsh, et al.
Publicado: (2013)

Germline mutation of TSC1 or TSC2 gene in Chinese patients with bilateral renal angiomyolipomas and mutation spectrum of Chinese TSC patients
por: Jiangyi, Wang, et al.
Publicado: (2020)

Hyperglycaemia, adverse outcomes and impact of intravenous insulin therapy in patients presenting with acute ST‐elevation myocardial infarction in a socioeconomically disadvantaged urban setting: The Montefiore STEMI Registry
por: Shitole, Sanyog G., et al.
Publicado: (2019)

Positional Cloning of Zinc Finger Domain Transcription Factor Zfp69, a Candidate Gene for Obesity-Associated Diabetes Contributed by Mouse Locus Nidd/SJL
por: Scherneck, Stephan, et al.
Publicado: (2009)

Hyperosmolar non-ketotic hyperglycaemia during oral diazoxide therapy of prolonged hyperglycaemia in infancy.
por: Savage, J. M., et al.
Publicado: (1977)

Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex
por: Li, Yi, et al.
Publicado: (2018)

Mutational analysis of TSC1 and TSC2 in Danish patients with tuberous sclerosis complex
por: Rosengren, Thomas, et al.
Publicado: (2020)

Correction: Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
por: Liu, Jie, et al.
Publicado: (2020)

Causes of Hyperglycæmia during Operation
por: De, P., et al.
Publicado: (1946)

Norepinephrine: Hyperglycaemia: case report
Publicado: (2020)

Hyperglycaemia-Related Visual Seizure
por: Thu, Win Myat, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tbkd8qc998c97mvnkrhtg3hj80