CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2

Tissue-resident memory CD8+ T (CD8 T(RM)) cells are an essential component of protective immune responses at barrier tissues, including the female genital tract. However, the mechanisms that lead to the initiation of CD8 T(RM)-mediated protective immunity after viral infection are unclear. Here we r...

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Autores principales: Shin, Haina, Kumamoto, Yosuke, Gopinath, Smita, Iwasaki, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105190/
https://www.ncbi.nlm.nih.gov/pubmed/27827367
http://dx.doi.org/10.1038/ncomms13346
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author Shin, Haina
Kumamoto, Yosuke
Gopinath, Smita
Iwasaki, Akiko
author_facet Shin, Haina
Kumamoto, Yosuke
Gopinath, Smita
Iwasaki, Akiko
author_sort Shin, Haina
collection PubMed
description Tissue-resident memory CD8+ T (CD8 T(RM)) cells are an essential component of protective immune responses at barrier tissues, including the female genital tract. However, the mechanisms that lead to the initiation of CD8 T(RM)-mediated protective immunity after viral infection are unclear. Here we report that CD8 T(RM) cells established by ‘prime and pull' method confer protection against genital HSV-2 infection, and that IFN-γ produced by CD8 T(RM) cells is required for this protection. Furthermore, we find that CD8 T(RM)-cell restimulation depends on a population of CD301b(+) antigen-presenting cells (APC) in the lamina propria. Elimination of MHC class I on CD301b(+) dendritic cells abrogates protective immunity, suggesting the requirement for cognate antigen presentation to CD8 T(RM) cells by CD301b(+) dendritic cells. These results define the requirements for CD8 T(RM) cells in protection against genital HSV-2 infection and identify the population of APC that are responsible for activating these cells.
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spelling pubmed-51051902016-11-18 CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2 Shin, Haina Kumamoto, Yosuke Gopinath, Smita Iwasaki, Akiko Nat Commun Article Tissue-resident memory CD8+ T (CD8 T(RM)) cells are an essential component of protective immune responses at barrier tissues, including the female genital tract. However, the mechanisms that lead to the initiation of CD8 T(RM)-mediated protective immunity after viral infection are unclear. Here we report that CD8 T(RM) cells established by ‘prime and pull' method confer protection against genital HSV-2 infection, and that IFN-γ produced by CD8 T(RM) cells is required for this protection. Furthermore, we find that CD8 T(RM)-cell restimulation depends on a population of CD301b(+) antigen-presenting cells (APC) in the lamina propria. Elimination of MHC class I on CD301b(+) dendritic cells abrogates protective immunity, suggesting the requirement for cognate antigen presentation to CD8 T(RM) cells by CD301b(+) dendritic cells. These results define the requirements for CD8 T(RM) cells in protection against genital HSV-2 infection and identify the population of APC that are responsible for activating these cells. Nature Publishing Group 2016-11-09 /pmc/articles/PMC5105190/ /pubmed/27827367 http://dx.doi.org/10.1038/ncomms13346 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Shin, Haina
Kumamoto, Yosuke
Gopinath, Smita
Iwasaki, Akiko
CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_full CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_fullStr CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_full_unstemmed CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_short CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
title_sort cd301b+ dendritic cells stimulate tissue-resident memory cd8+ t cells to protect against genital hsv-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105190/
https://www.ncbi.nlm.nih.gov/pubmed/27827367
http://dx.doi.org/10.1038/ncomms13346
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