Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Retromer is a membrane coat complex that is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. The timing of this interaction and consequent endosomal dynamics are thought to be regulated by the guanine nucleotide cycle of Rab7. Here we demonstrate that TBC1d5, a GTPase-activating...

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Detalles Bibliográficos
Autores principales: Jia, Da, Zhang, Jin-San, Li, Fang, Wang, Jing, Deng, Zhihui, White, Mark A., Osborne, Douglas G., Phillips-Krawczak, Christine, Gomez, Timothy S., Li, Haiying, Singla, Amika, Burstein, Ezra, Billadeau, Daniel D., Rosen, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105194/
https://www.ncbi.nlm.nih.gov/pubmed/27827364
http://dx.doi.org/10.1038/ncomms13305

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