Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function

Haploinsufficiency of the SYNGAP1 gene, which codes for a Ras GTPase-activating protein, impairs cognition both in humans and in mice. Decrease of Syngap1 in mice has been previously shown to cause cognitive deficits at least in part by inducing alterations in glutamatergic neurotransmission and pre...

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Detalles Bibliográficos
Autores principales: Berryer, Martin H., Chattopadhyaya, Bidisha, Xing, Paul, Riebe, Ilse, Bosoi, Ciprian, Sanon, Nathalie, Antoine-Bertrand, Judith, Lévesque, Maxime, Avoli, Massimo, Hamdan, Fadi F., Carmant, Lionel, Lamarche-Vane, Nathalie, Lacaille, Jean-Claude, Michaud, Jacques L., Di Cristo, Graziella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105197/
https://www.ncbi.nlm.nih.gov/pubmed/27827368
http://dx.doi.org/10.1038/ncomms13340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105197/
https://www.ncbi.nlm.nih.gov/pubmed/27827368
http://dx.doi.org/10.1038/ncomms13340

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