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Structure–Reactivity Effects on Intrinsic Primary Kinetic Isotope Effects for Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase
[Image: see text] Primary deuterium kinetic isotope effects (1°DKIE) on (k(cat)/K(GA), M(–1) s(–1)) for dianion (X(2–)) activated hydride transfer from NADL to glycolaldehyde (GA) catalyzed by glycerol-3-phosphate dehydrogenase were determined over a 2100-fold range of enzyme reactivity: (X(2–), 1°D...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105681/ https://www.ncbi.nlm.nih.gov/pubmed/27769116 http://dx.doi.org/10.1021/jacs.6b07028 |