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Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7

The transcription factor Pax7 plays a key role during embryonic myogenesis and in adult organisms in that it sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells. Recently we have shown that lack of Pax7 does not prevent the myogenic differentiation of plu...

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Autores principales: Czerwinska, Areta M., Nowacka, Joanna, Aszer, Magdalena, Gawrzak, Sylwia, Archacka, Karolina, Fogtman, Anna, Iwanicka-Nowicka, Roksana, Jańczyk-Ilach, Katarzyna, Koblowska, Marta, Ciemerych, Maria A., Grabowska, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105925/
https://www.ncbi.nlm.nih.gov/pubmed/27610933
http://dx.doi.org/10.1080/15384101.2016.1231260
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author Czerwinska, Areta M.
Nowacka, Joanna
Aszer, Magdalena
Gawrzak, Sylwia
Archacka, Karolina
Fogtman, Anna
Iwanicka-Nowicka, Roksana
Jańczyk-Ilach, Katarzyna
Koblowska, Marta
Ciemerych, Maria A.
Grabowska, Iwona
author_facet Czerwinska, Areta M.
Nowacka, Joanna
Aszer, Magdalena
Gawrzak, Sylwia
Archacka, Karolina
Fogtman, Anna
Iwanicka-Nowicka, Roksana
Jańczyk-Ilach, Katarzyna
Koblowska, Marta
Ciemerych, Maria A.
Grabowska, Iwona
author_sort Czerwinska, Areta M.
collection PubMed
description The transcription factor Pax7 plays a key role during embryonic myogenesis and in adult organisms in that it sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells. Recently we have shown that lack of Pax7 does not prevent the myogenic differentiation of pluripotent stem cells. In the current work we show that the absence of functional Pax7 in differentiating embryonic stem cells modulates cell cycle facilitating their proliferation. Surprisingly, deregulation of Pax7 function also positively impacts at the proliferation of mouse embryonic fibroblasts. Such phenotypes seem to be executed by modulating the expression of positive cell cycle regulators, such as cyclin E.
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spelling pubmed-51059252016-11-21 Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7 Czerwinska, Areta M. Nowacka, Joanna Aszer, Magdalena Gawrzak, Sylwia Archacka, Karolina Fogtman, Anna Iwanicka-Nowicka, Roksana Jańczyk-Ilach, Katarzyna Koblowska, Marta Ciemerych, Maria A. Grabowska, Iwona Cell Cycle Report The transcription factor Pax7 plays a key role during embryonic myogenesis and in adult organisms in that it sustains the proper function of satellite cells, which serve as adult skeletal muscle stem cells. Recently we have shown that lack of Pax7 does not prevent the myogenic differentiation of pluripotent stem cells. In the current work we show that the absence of functional Pax7 in differentiating embryonic stem cells modulates cell cycle facilitating their proliferation. Surprisingly, deregulation of Pax7 function also positively impacts at the proliferation of mouse embryonic fibroblasts. Such phenotypes seem to be executed by modulating the expression of positive cell cycle regulators, such as cyclin E. Taylor & Francis 2016-09-09 /pmc/articles/PMC5105925/ /pubmed/27610933 http://dx.doi.org/10.1080/15384101.2016.1231260 Text en © 2016 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Report
Czerwinska, Areta M.
Nowacka, Joanna
Aszer, Magdalena
Gawrzak, Sylwia
Archacka, Karolina
Fogtman, Anna
Iwanicka-Nowicka, Roksana
Jańczyk-Ilach, Katarzyna
Koblowska, Marta
Ciemerych, Maria A.
Grabowska, Iwona
Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7
title Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7
title_full Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7
title_fullStr Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7
title_full_unstemmed Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7
title_short Cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional Pax7
title_sort cell cycle regulation of embryonic stem cells and mouse embryonic fibroblasts lacking functional pax7
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105925/
https://www.ncbi.nlm.nih.gov/pubmed/27610933
http://dx.doi.org/10.1080/15384101.2016.1231260
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