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p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress
DNA replication initiation is a key event in the cell cycle, which is dependent on 2 kinases - CDK2 and CDC7. Here we report a novel mechanism in which p53 induces G1 checkpoint and cell cycle arrest by downregulating CDC7 kinase in response to genotoxic stress. We demonstrate that p53 controls CDC7...
Autores principales: | Tudzarova, Slavica, Mulholland, Paul, Dey, Ayona, Stoeber, Kai, Okorokov, Andrei L., Williams, Gareth H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105930/ https://www.ncbi.nlm.nih.gov/pubmed/27611229 http://dx.doi.org/10.1080/15384101.2016.1231281 |
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