Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

Mutations in TGFBR2, a component of the transforming growth factor (TGF)-β signaling pathway, occur in high-frequency microsatellite instability (MSI-H) colorectal cancer (CRC). In mouse models, Tgfbr2 inactivation in the intestinal epithelium accelerates the development of malignant intestinal tumo...

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Detalles Bibliográficos
Autores principales: Miguchi, Masashi, Hinoi, Takao, Shimomura, Manabu, Adachi, Tomohiro, Saito, Yasufumi, Niitsu, Hiroaki, Kochi, Masatoshi, Sada, Haruki, Sotomaru, Yusuke, Ikenoue, Tsuneo, Shigeyasu, Kunitoshi, Tanakaya, Kohji, Kitadai, Yasuhiko, Sentani, Kazuhiro, Oue, Naohide, Yasui, Wataru, Ohdan, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105946/
https://www.ncbi.nlm.nih.gov/pubmed/27835699
http://dx.doi.org/10.1371/journal.pone.0166422

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