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A Statistical Framework to Identify Deviation from Time Linearity in Epigenetic Aging

In multiple studies DNA methylation has proven to be an accurate biomarker of age. To develop these biomarkers, the methylation of multiple CpG sites is typically linearly combined to predict chronological age. By contrast, in this study we apply the Universal PaceMaker (UPM) model to investigate ch...

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Detalles Bibliográficos
Autores principales:	Snir, Sagi, vonHoldt, Bridgett M., Pellegrini, Matteo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106012/ https://www.ncbi.nlm.nih.gov/pubmed/27835646 http://dx.doi.org/10.1371/journal.pcbi.1005183

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