Cargando…
Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery
OBJECTIVE: Rheumatoid arthritis (RA) is a systemic disease that can affect the cervical spine, especially the atlantoaxial region. The present study evaluated the risk factors for atlantoaxial subluxation (AAS) development and progression in patients who have undergone surgical treatment. METHODS: W...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Neurosurgical Society
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106358/ https://www.ncbi.nlm.nih.gov/pubmed/27847572 http://dx.doi.org/10.3340/jkns.2016.59.6.590 |
_version_ | 1782467034982907904 |
---|---|
author | Na, Min-Kyun Chun, Hyoung-Joon Bak, Koang-Hum Yi, Hyeong-Joong Ryu, Je Il Han, Myung-Hoon |
author_facet | Na, Min-Kyun Chun, Hyoung-Joon Bak, Koang-Hum Yi, Hyeong-Joong Ryu, Je Il Han, Myung-Hoon |
author_sort | Na, Min-Kyun |
collection | PubMed |
description | OBJECTIVE: Rheumatoid arthritis (RA) is a systemic disease that can affect the cervical spine, especially the atlantoaxial region. The present study evaluated the risk factors for atlantoaxial subluxation (AAS) development and progression in patients who have undergone surgical treatment. METHODS: We retrospectively analyzed the data of 62 patients with RA and surgically treated AAS between 2002 and 2015. Additionally, we identified 62 patients as controls using propensity score matching of sex and age among 12667 RA patients from a rheumatology registry between 2007 and 2015. We extracted patient data, including sex, age at diagnosis, age at surgery, disease duration, radiographic hand joint changes, and history of methotrexate use, and laboratory data, including presence of rheumatoid factor and the C-reactive protein (CRP) level. RESULTS: The mean patient age at diagnosis was 38.0 years. The mean time interval between RA diagnosis and AAS surgery was 13.6±7.0 years. The risk factors for surgically treated AAS development were the serum CRP level (p=0.005) and radiographic hand joint erosion (p=0.009). The risk factors for AAS progression were a short time interval between RA diagnosis and radiographic hand joint erosion (p<0.001) and young age at RA diagnosis (p=0.04). CONCLUSION: The CRP level at RA diagnosis and a short time interval between RA diagnosis and radiographic hand joint erosion might be risk factors for surgically treated AAS development in RA patients. Additionally, a short time interval between RA diagnosis and radiographic hand joint erosion and young age at RA diagnosis might be risk factors for AAS progression. |
format | Online Article Text |
id | pubmed-5106358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-51063582016-11-15 Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery Na, Min-Kyun Chun, Hyoung-Joon Bak, Koang-Hum Yi, Hyeong-Joong Ryu, Je Il Han, Myung-Hoon J Korean Neurosurg Soc Clinical Article OBJECTIVE: Rheumatoid arthritis (RA) is a systemic disease that can affect the cervical spine, especially the atlantoaxial region. The present study evaluated the risk factors for atlantoaxial subluxation (AAS) development and progression in patients who have undergone surgical treatment. METHODS: We retrospectively analyzed the data of 62 patients with RA and surgically treated AAS between 2002 and 2015. Additionally, we identified 62 patients as controls using propensity score matching of sex and age among 12667 RA patients from a rheumatology registry between 2007 and 2015. We extracted patient data, including sex, age at diagnosis, age at surgery, disease duration, radiographic hand joint changes, and history of methotrexate use, and laboratory data, including presence of rheumatoid factor and the C-reactive protein (CRP) level. RESULTS: The mean patient age at diagnosis was 38.0 years. The mean time interval between RA diagnosis and AAS surgery was 13.6±7.0 years. The risk factors for surgically treated AAS development were the serum CRP level (p=0.005) and radiographic hand joint erosion (p=0.009). The risk factors for AAS progression were a short time interval between RA diagnosis and radiographic hand joint erosion (p<0.001) and young age at RA diagnosis (p=0.04). CONCLUSION: The CRP level at RA diagnosis and a short time interval between RA diagnosis and radiographic hand joint erosion might be risk factors for surgically treated AAS development in RA patients. Additionally, a short time interval between RA diagnosis and radiographic hand joint erosion and young age at RA diagnosis might be risk factors for AAS progression. The Korean Neurosurgical Society 2016-11 2016-10-24 /pmc/articles/PMC5106358/ /pubmed/27847572 http://dx.doi.org/10.3340/jkns.2016.59.6.590 Text en Copyright © 2016 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Article Na, Min-Kyun Chun, Hyoung-Joon Bak, Koang-Hum Yi, Hyeong-Joong Ryu, Je Il Han, Myung-Hoon Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery |
title | Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery |
title_full | Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery |
title_fullStr | Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery |
title_full_unstemmed | Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery |
title_short | Risk Factors for the Development and Progression of Atlantoaxial Subluxation in Surgically Treated Rheumatoid Arthritis Patients, Considering the Time Interval between Rheumatoid Arthritis Diagnosis and Surgery |
title_sort | risk factors for the development and progression of atlantoaxial subluxation in surgically treated rheumatoid arthritis patients, considering the time interval between rheumatoid arthritis diagnosis and surgery |
topic | Clinical Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106358/ https://www.ncbi.nlm.nih.gov/pubmed/27847572 http://dx.doi.org/10.3340/jkns.2016.59.6.590 |
work_keys_str_mv | AT naminkyun riskfactorsforthedevelopmentandprogressionofatlantoaxialsubluxationinsurgicallytreatedrheumatoidarthritispatientsconsideringthetimeintervalbetweenrheumatoidarthritisdiagnosisandsurgery AT chunhyoungjoon riskfactorsforthedevelopmentandprogressionofatlantoaxialsubluxationinsurgicallytreatedrheumatoidarthritispatientsconsideringthetimeintervalbetweenrheumatoidarthritisdiagnosisandsurgery AT bakkoanghum riskfactorsforthedevelopmentandprogressionofatlantoaxialsubluxationinsurgicallytreatedrheumatoidarthritispatientsconsideringthetimeintervalbetweenrheumatoidarthritisdiagnosisandsurgery AT yihyeongjoong riskfactorsforthedevelopmentandprogressionofatlantoaxialsubluxationinsurgicallytreatedrheumatoidarthritispatientsconsideringthetimeintervalbetweenrheumatoidarthritisdiagnosisandsurgery AT ryujeil riskfactorsforthedevelopmentandprogressionofatlantoaxialsubluxationinsurgicallytreatedrheumatoidarthritispatientsconsideringthetimeintervalbetweenrheumatoidarthritisdiagnosisandsurgery AT hanmyunghoon riskfactorsforthedevelopmentandprogressionofatlantoaxialsubluxationinsurgicallytreatedrheumatoidarthritispatientsconsideringthetimeintervalbetweenrheumatoidarthritisdiagnosisandsurgery |