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Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea
Marine sediments accommodate plethora of diverse microorganisms with varying ecological functions. In the present study, we isolated bacteria from surficial sediments of south east Arabian Sea (AS) and evaluated their bioactive potentials. A total of 131 isolates belonging to the phylum: γ-Proteobac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106401/ https://www.ncbi.nlm.nih.gov/pubmed/28330310 http://dx.doi.org/10.1007/s13205-016-0556-x |
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author | Anas, Abdulaziz Nilayangod, Charulatha Jasmin, C. Vinothkumar, Saradavey Parameswaran, P. S. Nair, Shanta |
author_facet | Anas, Abdulaziz Nilayangod, Charulatha Jasmin, C. Vinothkumar, Saradavey Parameswaran, P. S. Nair, Shanta |
author_sort | Anas, Abdulaziz |
collection | PubMed |
description | Marine sediments accommodate plethora of diverse microorganisms with varying ecological functions. In the present study, we isolated bacteria from surficial sediments of south east Arabian Sea (AS) and evaluated their bioactive potentials. A total of 131 isolates belonging to the phylum: γ-Proteobacteria (63%), Bacillales (34%) and Micrococcaceae (3%) were isolated. Among these, about 40% of the isolates showed the presence of secondary metabolite biosynthetic genes such as PKS or NRPS or both. Organic extracts of nearly 50% of these organisms were cytotoxic to human breast cancer MCF-7 cells and were bactericidal to human pathogens, Escherichia coli and Pseudomonas sp., while 20–30% of them were bactericidal to Vibrio sp. and Staphylococcus sp. too. In all, 8 isolates, belonging to Pseudomonas spp., Bacillus sp. and/or Lysinibacillus sp. displayed high level of bactericidal/cytotoxic properties. The study proposes AS sediment as a rich source for microorganisms with prospective bioactive molecules. |
format | Online Article Text |
id | pubmed-5106401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-51064012016-11-14 Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea Anas, Abdulaziz Nilayangod, Charulatha Jasmin, C. Vinothkumar, Saradavey Parameswaran, P. S. Nair, Shanta 3 Biotech Original Article Marine sediments accommodate plethora of diverse microorganisms with varying ecological functions. In the present study, we isolated bacteria from surficial sediments of south east Arabian Sea (AS) and evaluated their bioactive potentials. A total of 131 isolates belonging to the phylum: γ-Proteobacteria (63%), Bacillales (34%) and Micrococcaceae (3%) were isolated. Among these, about 40% of the isolates showed the presence of secondary metabolite biosynthetic genes such as PKS or NRPS or both. Organic extracts of nearly 50% of these organisms were cytotoxic to human breast cancer MCF-7 cells and were bactericidal to human pathogens, Escherichia coli and Pseudomonas sp., while 20–30% of them were bactericidal to Vibrio sp. and Staphylococcus sp. too. In all, 8 isolates, belonging to Pseudomonas spp., Bacillus sp. and/or Lysinibacillus sp. displayed high level of bactericidal/cytotoxic properties. The study proposes AS sediment as a rich source for microorganisms with prospective bioactive molecules. Springer Berlin Heidelberg 2016-11-11 2016-12 /pmc/articles/PMC5106401/ /pubmed/28330310 http://dx.doi.org/10.1007/s13205-016-0556-x Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Anas, Abdulaziz Nilayangod, Charulatha Jasmin, C. Vinothkumar, Saradavey Parameswaran, P. S. Nair, Shanta Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea |
title | Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea |
title_full | Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea |
title_fullStr | Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea |
title_full_unstemmed | Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea |
title_short | Diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the Arabian Sea |
title_sort | diversity and bioactive potentials of culturable heterotrophic bacteria from the surficial sediments of the arabian sea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106401/ https://www.ncbi.nlm.nih.gov/pubmed/28330310 http://dx.doi.org/10.1007/s13205-016-0556-x |
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