Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles

ABSTRACT: By cycloaddition reaction of sodium azide with chalcone in the presence of CuO as a catalyst in DMF a 1,2,3-triazole are prepared in reaction with pentafluoropyridine to give 2-(tetrafluoropyridin-4-yl)-1,2,3-triazole derivatives in good yields and high regioselectivity. The regioselectivi...

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Autores principales: Beyki, Khalil, Maghsoodlou, Malek Taher, Heydari, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106409/
https://www.ncbi.nlm.nih.gov/pubmed/27933240
http://dx.doi.org/10.1186/s40064-016-3398-4
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author Beyki, Khalil
Maghsoodlou, Malek Taher
Heydari, Reza
author_facet Beyki, Khalil
Maghsoodlou, Malek Taher
Heydari, Reza
author_sort Beyki, Khalil
collection PubMed
description ABSTRACT: By cycloaddition reaction of sodium azide with chalcone in the presence of CuO as a catalyst in DMF a 1,2,3-triazole are prepared in reaction with pentafluoropyridine to give 2-(tetrafluoropyridin-4-yl)-1,2,3-triazole derivatives in good yields and high regioselectivity. The regioselectivity of the compounds are confirmed by (19)F-NMR and other spectroscopy. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-51064092016-12-08 Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles Beyki, Khalil Maghsoodlou, Malek Taher Heydari, Reza Springerplus Short Report ABSTRACT: By cycloaddition reaction of sodium azide with chalcone in the presence of CuO as a catalyst in DMF a 1,2,3-triazole are prepared in reaction with pentafluoropyridine to give 2-(tetrafluoropyridin-4-yl)-1,2,3-triazole derivatives in good yields and high regioselectivity. The regioselectivity of the compounds are confirmed by (19)F-NMR and other spectroscopy. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2016-11-11 /pmc/articles/PMC5106409/ /pubmed/27933240 http://dx.doi.org/10.1186/s40064-016-3398-4 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Short Report
Beyki, Khalil
Maghsoodlou, Malek Taher
Heydari, Reza
Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
title Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
title_full Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
title_fullStr Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
title_full_unstemmed Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
title_short Synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
title_sort synthesis of 2-tetrafluoropyridyl-4,5-disubstituted 1,2,3-triazoles
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106409/
https://www.ncbi.nlm.nih.gov/pubmed/27933240
http://dx.doi.org/10.1186/s40064-016-3398-4
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