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Carbonyl reductase identification and development of whole-cell biotransformation for highly efficient synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol

BACKGROUND: (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol [(R)-3,5-BTPE] is a valuable chiral intermediate for Aprepitant (Emend) and Fosaprepitant (Ivemend). Biocatalyzed asymmetric reduction is a preferred approach to synthesize highly optically active (R)-3,5-BTPE. However, the product concentrati...

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Detalles Bibliográficos
Autores principales:	Chen, Kangling, Li, Kefei, Deng, Jian, Zhang, Baoqi, Lin, Jinping, Wei, Dongzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106766/ https://www.ncbi.nlm.nih.gov/pubmed/27835967 http://dx.doi.org/10.1186/s12934-016-0585-5

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