Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes

BACKGROUND: The KMT2A/MLL1 lysine methyltransferase complex is an epigenetic regulator of selected developmental genes, in part through the SET domain-catalysed methylation of H3K4. It is essential for normal embryonic development and haematopoiesis and frequently mutated in cancer. The catalytic pr...

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Detalles Bibliográficos
Autores principales: Wiersma, Maaike, Bussiere, Marianne, Halsall, John A., Turan, Nil, Slany, Robert, Turner, Bryan M., Nightingale, Karl P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5106815/
https://www.ncbi.nlm.nih.gov/pubmed/27895715
http://dx.doi.org/10.1186/s13072-016-0103-3

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