Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer

Cystathionine-β-synthase (CBS) has been recently identified as a drug target for several forms of cancer. Currently no potent and selective CBS inhibitors are available. Using a composite collection of 8871 clinically used drugs and well-annotated pharmacological compounds (including the LOPAC libra...

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Detalles Bibliográficos
Autores principales: Druzhyna, Nadiya, Szczesny, Bartosz, Olah, Gabor, Módis, Katalin, Asimakopoulou, Antonia, Pavlidou, Athanasia, Szoleczky, Petra, Gerö, Domokos, Yanagi, Kazunori, Törö, Gabor, López-García, Isabel, Myrianthopoulos, Vassilios, Mikros, Emmanuel, Zatarain, John R., Chao, Celia, Papapetropoulos, Andreas, Hellmich, Mark R., Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107130/
https://www.ncbi.nlm.nih.gov/pubmed/27521834
http://dx.doi.org/10.1016/j.phrs.2016.08.016

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