Cargando…

Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays

Overexpression of coactivator associated arginine methyltransferase 1 (CARM1), a protein arginine N-methyltransferase (PRMT) family enzyme, is associated with various diseases including cancers. Consequently, the development of small-molecule inhibitors targeting PRMTs has significant value for both...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Fei, Zhang, Weiyao, Lu, Wenchao, Xie, Yiqian, Jiang, Hao, Jin, Jia, Luo, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107250/ https://www.ncbi.nlm.nih.gov/pubmed/27872854 http://dx.doi.org/10.1155/2016/7086390

Ejemplares similares

A Direct Assay for Measuring the Activity and Inhibition of Coactivator-Associated Arginine Methyltransferase 1
por: Zhang, Yurui, et al.
Publicado: (2022)

Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development
por: Ma, Zhongrui, et al.
Publicado: (2022)

Role of Coactivator Associated Arginine Methyltransferase 1 (CARM1) in the Regulation of the Biological Function of 1,25-Dihydroxyvitamin D(3)
por: Mady, Leila J., et al.
Publicado: (2023)

Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening
por: Wang, Qianqian, et al.
Publicado: (2018)

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction
por: Coelho, Fernanda Sales, et al.
Publicado: (2023)

Corrigendum: Schistosoma mansoni coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction
por: Coelho, Fernanda Sales, et al.
Publicado: (2023)

Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay
por: Aouadi, Wahiba, et al.
Publicado: (2017)

Structural biology and chemistry of protein arginine methyltransferases
por: Schapira, Matthieu, et al.
Publicado: (2014)

Exploration of Cyanine Compounds as Selective Inhibitors of Protein Arginine Methyltransferases: Synthesis and Biological Evaluation
por: Hu, Hao, et al.
Publicado: (2015)

The effect of cell penetrating peptide-conjugated coactivator-associated arginine methyltransferase 1 (CPP-CARM1) on the cloned mouse embryonic development
por: Bang, Jae-Il, et al.
Publicado: (2018)

Protein arginine methyltransferase 6 is a novel substrate of protein arginine methyltransferase 1
por: Cao, Meng-Tong, et al.
Publicado: (2023)

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays
por: Liu, Yaodong, et al.
Publicado: (2022)

A Pan-Inhibitor for Protein Arginine Methyltransferase Family Enzymes
por: Iyamu, Iredia D., et al.
Publicado: (2021)

Identification and Characterization of Protein Arginine Methyltransferase 1 in Acanthamoeba castellanii
por: Moon, Eun-Kyung, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Novel and Potent Protein Arginine Methyltransferases 5 Inhibitors for Cancer Therapy
por: Tang, Yixuan, et al.
Publicado: (2022)

Arginine methyltransferase inhibitor-1 inhibits sarcoma viability in vitro and in vivo
por: Zhang, Baolai, et al.
Publicado: (2018)

Licochalcone A is a natural selective inhibitor of arginine methyltransferase 6
por: Gong, Shuai, et al.
Publicado: (2021)

Identification of xanthine oxidase inhibitors through hierarchical virtual screening
por: Yang, Ying, et al.
Publicado: (2020)

Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
por: Iannelli, Giulia, et al.
Publicado: (2022)

The Role and Mechanism of Lysine Methyltransferase and Arginine Methyltransferase in Kidney Diseases
por: Zhou, Xun, et al.
Publicado: (2022)

Identification of Protein Arginine Methyltransferase 5 as a Regulator for Encystation of Acanthamoeba
por: Moon, Eun-Kyung, et al.
Publicado: (2016)

Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family
por: Li, Fei, et al.
Publicado: (2019)

Identification of Potent Zika Virus NS5 RNA-Dependent RNA Polymerase Inhibitors Combining Virtual Screening and Biological Assays
por: Chen, Ying, et al.
Publicado: (2023)

Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr
por: Carbonell, Albert, et al.
Publicado: (2013)

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors
por: Sun, Yutong, et al.
Publicado: (2019)

Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors
por: Brown, Tyler, et al.
Publicado: (2022)

Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus
por: Lim, See Ven, et al.
Publicado: (2011)

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
por: Kaniskan, H. Ümit, et al.
Publicado: (2017)

Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase
por: Zhou, Jujun, et al.
Publicado: (2023)

The Role of Protein Arginine Methyltransferases in Inflammatory Responses
por: Kim, Ji Hye, et al.
Publicado: (2016)

Protein Arginine Methyltransferases in Neuromuscular Function and Diseases
por: Lee, Jinwoo, et al.
Publicado: (2022)

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors
por: Lin, Hong, et al.
Publicado: (2019)

Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay
por: Bobenchik, April M, et al.
Publicado: (2010)

Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1
por: Zhang, Ruihan, et al.
Publicado: (2013)

Identification and Characterization of New Molecular Partners for the Protein Arginine Methyltransferase 6 (PRMT6)
por: Lo Sardo, Alessandra, et al.
Publicado: (2013)

The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
por: Bai, Xuemei, et al.
Publicado: (2022)

Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors
por: Zhang, Gongliang, et al.
Publicado: (2019)

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation
por: Kolodziej, Stephan, et al.
Publicado: (2014)

Roles of Protein Arginine Methyltransferases in the Control of Glucose Metabolism
por: Han, Hye-Sook, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5l6v5naohlo4edjs29tk9v9ku2