Cargando…

Efficacy and safety of levetiracetam in the management of seizures in neonates

OBJECTIVE: To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates. METHODS: A prospective non-blind, single arm clinical trial conducted in the Department of Neonatology and Pediatric Intensive Care, Mohamad Kermanshahi, and Imam Reza Hospital, Kermansha...

Descripción completa

Detalles Bibliográficos
Autores principales: Sedighi, Mostafa, Asadi, Farzaneh, Moradian, Nasrin, Vakiliamini, Mazyar, Moradian, Mohamad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Riyadh : Armed Forces Hospital 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107289/
https://www.ncbi.nlm.nih.gov/pubmed/27356654
http://dx.doi.org/10.17712/nsj.2016.3.20150726
_version_ 1782467193170034688
author Sedighi, Mostafa
Asadi, Farzaneh
Moradian, Nasrin
Vakiliamini, Mazyar
Moradian, Mohamad
author_facet Sedighi, Mostafa
Asadi, Farzaneh
Moradian, Nasrin
Vakiliamini, Mazyar
Moradian, Mohamad
author_sort Sedighi, Mostafa
collection PubMed
description OBJECTIVE: To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates. METHODS: A prospective non-blind, single arm clinical trial conducted in the Department of Neonatology and Pediatric Intensive Care, Mohamad Kermanshahi, and Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran from May 2014 to December 2014. Fifty out of 60 newborns with gestational age ≥30 weeks with clinically diagnosed seizures were included. Levetiracetam was administered orally with an initial dose of 10 mg/kg twice a day. The patients were observed continuously by Neuro Intensive Care nurses, and visited daily by a neuropediatrician in the first 7 days and then at days 14, 30, and 90 after the start of LEV administration. Clinical examination was performed for every patient, and seizure number, antiepileptic medication, and adverse events were detailed at every visit. RESULTS: 47 infants were seizure free under LEV at the end of the first week, 47remained seizure free at 4 weeks, and 46 remained seizure free at 11 weeks. No immediate and long-term side effects were noted in our patients. CONCLUSION: This study investigated the efficacy and safety of LEV in neonatal seizure control but confirmation with further randomized controlled trials is required.
format Online
Article
Text
id pubmed-5107289
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Riyadh : Armed Forces Hospital
record_format MEDLINE/PubMed
spelling pubmed-51072892016-11-17 Efficacy and safety of levetiracetam in the management of seizures in neonates Sedighi, Mostafa Asadi, Farzaneh Moradian, Nasrin Vakiliamini, Mazyar Moradian, Mohamad Neurosciences (Riyadh) Original Article OBJECTIVE: To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates. METHODS: A prospective non-blind, single arm clinical trial conducted in the Department of Neonatology and Pediatric Intensive Care, Mohamad Kermanshahi, and Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran from May 2014 to December 2014. Fifty out of 60 newborns with gestational age ≥30 weeks with clinically diagnosed seizures were included. Levetiracetam was administered orally with an initial dose of 10 mg/kg twice a day. The patients were observed continuously by Neuro Intensive Care nurses, and visited daily by a neuropediatrician in the first 7 days and then at days 14, 30, and 90 after the start of LEV administration. Clinical examination was performed for every patient, and seizure number, antiepileptic medication, and adverse events were detailed at every visit. RESULTS: 47 infants were seizure free under LEV at the end of the first week, 47remained seizure free at 4 weeks, and 46 remained seizure free at 11 weeks. No immediate and long-term side effects were noted in our patients. CONCLUSION: This study investigated the efficacy and safety of LEV in neonatal seizure control but confirmation with further randomized controlled trials is required. Riyadh : Armed Forces Hospital 2016-07 /pmc/articles/PMC5107289/ /pubmed/27356654 http://dx.doi.org/10.17712/nsj.2016.3.20150726 Text en Copyright: © Neurosciences Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Article
Sedighi, Mostafa
Asadi, Farzaneh
Moradian, Nasrin
Vakiliamini, Mazyar
Moradian, Mohamad
Efficacy and safety of levetiracetam in the management of seizures in neonates
title Efficacy and safety of levetiracetam in the management of seizures in neonates
title_full Efficacy and safety of levetiracetam in the management of seizures in neonates
title_fullStr Efficacy and safety of levetiracetam in the management of seizures in neonates
title_full_unstemmed Efficacy and safety of levetiracetam in the management of seizures in neonates
title_short Efficacy and safety of levetiracetam in the management of seizures in neonates
title_sort efficacy and safety of levetiracetam in the management of seizures in neonates
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107289/
https://www.ncbi.nlm.nih.gov/pubmed/27356654
http://dx.doi.org/10.17712/nsj.2016.3.20150726
work_keys_str_mv AT sedighimostafa efficacyandsafetyoflevetiracetaminthemanagementofseizuresinneonates
AT asadifarzaneh efficacyandsafetyoflevetiracetaminthemanagementofseizuresinneonates
AT moradiannasrin efficacyandsafetyoflevetiracetaminthemanagementofseizuresinneonates
AT vakiliaminimazyar efficacyandsafetyoflevetiracetaminthemanagementofseizuresinneonates
AT moradianmohamad efficacyandsafetyoflevetiracetaminthemanagementofseizuresinneonates