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Efficacy and safety of levetiracetam in the management of seizures in neonates
OBJECTIVE: To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates. METHODS: A prospective non-blind, single arm clinical trial conducted in the Department of Neonatology and Pediatric Intensive Care, Mohamad Kermanshahi, and Imam Reza Hospital, Kermansha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Riyadh : Armed Forces Hospital
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107289/ https://www.ncbi.nlm.nih.gov/pubmed/27356654 http://dx.doi.org/10.17712/nsj.2016.3.20150726 |
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author | Sedighi, Mostafa Asadi, Farzaneh Moradian, Nasrin Vakiliamini, Mazyar Moradian, Mohamad |
author_facet | Sedighi, Mostafa Asadi, Farzaneh Moradian, Nasrin Vakiliamini, Mazyar Moradian, Mohamad |
author_sort | Sedighi, Mostafa |
collection | PubMed |
description | OBJECTIVE: To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates. METHODS: A prospective non-blind, single arm clinical trial conducted in the Department of Neonatology and Pediatric Intensive Care, Mohamad Kermanshahi, and Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran from May 2014 to December 2014. Fifty out of 60 newborns with gestational age ≥30 weeks with clinically diagnosed seizures were included. Levetiracetam was administered orally with an initial dose of 10 mg/kg twice a day. The patients were observed continuously by Neuro Intensive Care nurses, and visited daily by a neuropediatrician in the first 7 days and then at days 14, 30, and 90 after the start of LEV administration. Clinical examination was performed for every patient, and seizure number, antiepileptic medication, and adverse events were detailed at every visit. RESULTS: 47 infants were seizure free under LEV at the end of the first week, 47remained seizure free at 4 weeks, and 46 remained seizure free at 11 weeks. No immediate and long-term side effects were noted in our patients. CONCLUSION: This study investigated the efficacy and safety of LEV in neonatal seizure control but confirmation with further randomized controlled trials is required. |
format | Online Article Text |
id | pubmed-5107289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Riyadh : Armed Forces Hospital |
record_format | MEDLINE/PubMed |
spelling | pubmed-51072892016-11-17 Efficacy and safety of levetiracetam in the management of seizures in neonates Sedighi, Mostafa Asadi, Farzaneh Moradian, Nasrin Vakiliamini, Mazyar Moradian, Mohamad Neurosciences (Riyadh) Original Article OBJECTIVE: To evaluate the efficacy and safety of levetiracetam (LEV) in the management of seizures in neonates. METHODS: A prospective non-blind, single arm clinical trial conducted in the Department of Neonatology and Pediatric Intensive Care, Mohamad Kermanshahi, and Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran from May 2014 to December 2014. Fifty out of 60 newborns with gestational age ≥30 weeks with clinically diagnosed seizures were included. Levetiracetam was administered orally with an initial dose of 10 mg/kg twice a day. The patients were observed continuously by Neuro Intensive Care nurses, and visited daily by a neuropediatrician in the first 7 days and then at days 14, 30, and 90 after the start of LEV administration. Clinical examination was performed for every patient, and seizure number, antiepileptic medication, and adverse events were detailed at every visit. RESULTS: 47 infants were seizure free under LEV at the end of the first week, 47remained seizure free at 4 weeks, and 46 remained seizure free at 11 weeks. No immediate and long-term side effects were noted in our patients. CONCLUSION: This study investigated the efficacy and safety of LEV in neonatal seizure control but confirmation with further randomized controlled trials is required. Riyadh : Armed Forces Hospital 2016-07 /pmc/articles/PMC5107289/ /pubmed/27356654 http://dx.doi.org/10.17712/nsj.2016.3.20150726 Text en Copyright: © Neurosciences Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. |
spellingShingle | Original Article Sedighi, Mostafa Asadi, Farzaneh Moradian, Nasrin Vakiliamini, Mazyar Moradian, Mohamad Efficacy and safety of levetiracetam in the management of seizures in neonates |
title | Efficacy and safety of levetiracetam in the management of seizures in neonates |
title_full | Efficacy and safety of levetiracetam in the management of seizures in neonates |
title_fullStr | Efficacy and safety of levetiracetam in the management of seizures in neonates |
title_full_unstemmed | Efficacy and safety of levetiracetam in the management of seizures in neonates |
title_short | Efficacy and safety of levetiracetam in the management of seizures in neonates |
title_sort | efficacy and safety of levetiracetam in the management of seizures in neonates |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107289/ https://www.ncbi.nlm.nih.gov/pubmed/27356654 http://dx.doi.org/10.17712/nsj.2016.3.20150726 |
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