Engineering Translation in Mammalian Cell Factories to Increase Protein Yield: The Unexpected Use of Long Non-Coding SINEUP RNAs

Mammalian cells are an indispensable tool for the production of recombinant proteins in contexts where function depends on post-translational modifications. Among them, Chinese Hamster Ovary (CHO) cells are the primary factories for the production of therapeutic proteins, including monoclonal antibo...

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Detalles Bibliográficos
Autores principales: Zucchelli, Silvia, Patrucco, Laura, Persichetti, Francesca, Gustincich, Stefano, Cotella, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2016
Materias:
Short Survey
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107644/
https://www.ncbi.nlm.nih.gov/pubmed/27872686
http://dx.doi.org/10.1016/j.csbj.2016.10.004

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