Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an adaptive mechanism generally activated by mild oxidative stress to protect the cells from further damage. Many phytochemica...

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Detalles Bibliográficos
Autores principales: Zhang, Chao, Li, Chuwen, Chen, Shenghui, Li, Zhiping, Jia, Xuejing, Wang, Kai, Bao, Jiaolin, Liang, Yeer, Wang, Xiaotong, Chen, Meiwan, Li, Peng, Su, Huanxing, Wan, Jian-Bo, Lee, Simon Ming Yuen, Liu, Kechun, He, Chengwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107737/
https://www.ncbi.nlm.nih.gov/pubmed/27835779
http://dx.doi.org/10.1016/j.redox.2016.10.019

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